Volume 12 | Issue 1 |

 Abstract

Mirabegron opened a new period in the treatment of hyperactive bladder( OAB) For the first time croakerealing with OAB have an effective volition to the pharmacological dependence of the remedy for this complaint, the antimuscarinic medicines. This first- by- class, potent ?3- adrenoceptors agonist has lately entered blessing by nonsupervisory authorities in Japan, United States and Europe, grounded on the favourable efficacity- tolerability profile demonstrated in multiple randomized, transnational, controlled trials, both short and long- term. Mirabegron is a novel, formerly- daily, orally active, first- in- class, potent ?3- adrenoceptor agonist lately approved by Food and Drug Administration for hyperactive bladder remedy. Phase II studies and four large- scale phase III transnational randomized, controlled trials have supported the efficacity and tolerability of mirabegron & vibegron in the clinical trial setting of cases with hyperactive bladder for over to 12 weeks of remedy and in the long term( 12 months). The reported prevalence and inflexibility of treatment- emergent and serious adverse goods were analogous to antimuscarinics. Vibegron is, in discrepancy to other OAB medicines, veritably picky and leads to a lower degree of unwanted side goods. Vibegron is set up to be a substrate for CYP3A4 in vivo, but doesn't actually induce or inhibit any of the cytochrome P450 enzymes and is therefore less likely to take part in medicine - medicine relations( DDI). Then vibegron differs from the former hyperactive bladder medicine mirabegron, which was known to be associated in colorful medicine - medicine relations.

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 Keywords

Mirabegron , vibegron , antimuscarinic Agent , ?3- adrenoceptor Agonist ,Overactive Bladder

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Stress is a universal phenomenon that essentially manifests itself in humans as a result of pressure emanating from several experiences or challenging situation. Delay in job completion, deterioration of the power of organization and planning, increase in error rate during manipulative and cognitive task, depression and feeling of helplessness and over sensitivity are the major impact of stress on the productivity of professionals. In order to minimize stress, delegating some work, share burden with colleagues, leave and time off work with family and loved ones, as well as reducing work overtime ranked highest as strategies for stress management. Based on the findings, it was concluded that stress has a great impact on the professionals and thereby affects the level of productivity. It was therefore recommended that professionals should exhibit self-control and good self-esteem; engage in continuous professional development on skills for better organization, integration of work within specified project constraints and delegation of assignments, authority and breaking work into manageable parts so as to be able to cope with stress. An attempt has been made through this research paper to know the reasons of stress among the employees and the ways used by employees to cope with the stress generated at workplace. In the second part of the article some stress coping strategies, such as gaining social support, taking advantage of the programs targeting on stress coping, reduction of stress in the workplace by improving work environment and work organization, are explained.

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 Keywords

Stress, Stress Management, Industries, Workplace, Factors

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The growth trend of luxury cars in the global market has been marked by a steady rise in demand driven by economic prosperity, changing consumer preferences, and expanding high-net-worth populations. It is in this context, that a modest attempt has been made to present the growth trend of luxury cars in the global market, the evolving scenario in India's luxury car market. This study reveals that the global luxury car market demonstrated that Mercedes-Benz leads in global market share, increasing from 25.2% in 2020 to 31.2% in 2022. BMW, the second-largest player, experiences a slight decline, while Audi faces a decrease in market share. The luxury car market is anticipated to generate revenue of US$19,500m by 2024, with the United States contributing the most. However, in India, BMW dominates the luxury car market with a market share increase from 40.7% in 2020 to 48.0% in 2022, despite a decline in unit sales. Mercedes-Benz maintains a significant market share, while Jaguar Land Rover and Volvo experience declines in both market share and unit sales. The total luxury car market in India sees a decline in unit sales from 27,196 in 2021 to 16,467 in 2022, reflecting challenges and changes in the Indian luxury car segment.

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Luxury cars, automotive industry, Buyer preferences, impact of global brands, technological advancements.

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This paper delves into the realm of behavioural finance, exploring the psychological and emotional factors shaping investment decisions. It challenges the traditional assumption of rational decision-making in financial markets, asserting that individuals are influenced by emotions. Cognitive biases and social dynamics the study underscores the profound impact of emotional biases, varying risk perceptions, and cognitive biases on investor choices through a mixed-methods approach combining existing literature with primary data collected through surveys. Factors influencing investment choices, providing a foundation for interventions and educational resources aimed at fostering informed and rational investment practices in an evolving financial landscape.

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Behavioural, Finance, Savings, Investment, wealth maximization, capital safeguarding, financial institutions, emerging markets.

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 Abstract

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Mangal

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This research paper delves into the evolving role of civil society in driving police reforms, with a particular focus on the contemporary challenges faced by society as well as law enforcement agencies in India. Indian Police System faces many challenges like trust deficit, transparency, corruption issues, etc. This paper highlights many such issues that the police face and that can be rectified by the involvement of the civil societies. The paper explores innovative and improved ways in which civil society can actively contribute to shaping a more accountable, transparent, and responsive police system. In the context of modern-day crimes and the changing landscape of law enforcement, the research examines the crucial intersections between civil society and the Indian police, proposing strategies to enhance collaboration for effective reform for the better engagement of the society and the future policing reforms that are needed to make the India great.

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Police Reforms, Indian Police System, Civil Society, Case study of Police Reforms in Various Countries, Challenges in Police System

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The purpose of the current study was to determine how long tribal male and female paramedical college students in Tripura spent relaxing. The outcome captures the social perspective of both male and female college students. According to the report, men students have four to five hours more of free time than their female peers. The majority of female students only considered 30 to 1 hour to be free time. The primary cause discovered is that female students have greater family duties than male pupils.

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Leisure activity duration, male, female, tribal, college students, paramedical

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Mathematics is composed of a number of areas each having their very own distinct characteristics. Graph Theory is one among the area which is becoming popular. Graph Theory is the study of graphs which allow us to picturize the data and helps us to simplify the complex structure of the data. In recent years, graph theory has established itself as an important mathematical tool in variety of subjects ranging from Operations research and chemistry to sociology and architecture. At the same time it has also emerged as a worthwhile mathematical discipline in its own right. A variety of papers based on Graph theory and its applications have been studied and an overview has been presented here.

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Directed Graph, Bipartite graph, Binary Tree, Vertex Colouring.

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A social cause is a problem that influences a considerable number of individuals within a society. It is often the consequence of factors extending beyond an individual's control, and is the source of a conflicting opinion on the grounds of what is perceived as a morally just personal life or societal order Social issues are distinguished from economic issues; however, some issues (such as immigration) have both social and economic aspects. There are also issues that don't fall into either category, such as warfare.

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Society, Social issues,Corruption, Poverty

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Amyotrophic lateral sclerosis (ALS), is an incredibly rare neurological disorder that affects motor neurons, which are nerve cells in the brain and spinal cord that control voluntary muscle movement. The first reported case of ALS was 200 years ago by Charles Bell. There are two kinds of ALS. The etiologic and neuropathologic process of ALS was elucidated. Neuronal degeneration is the major mechanism. Mutation of various genes is its genetic contribution. Risk factors including smoking, diet and balanced weight plays a crucial role in ALS. Symptoms of ALS from the early stage to the life threatening is explained. ALS is diagnosed by diagnostic criteria. The only treatment option in ALS is riluzole and others are symptomatic management.

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Amyotropic lateral sclerosis, Etiology, Neuropathology, Risk factors, Treatment

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