Volume 13 | Issue 1 |

 Abstract

Pharmacogenomics is transforming personalized medicine by tailoring medication regimens to a patient's genetic composition, with a special emphasis on single nucleotide polymorphisms. This paper explores the two primary approaches utilized in SNP-based research: LD mapping, which searches the whole genome for SNP-related connections, and the candidate gene method, which looks at particular genes known to affect medication reactions. Applications of these approaches in diseases such as rheumatoid arthritis serve as examples. In this case, genetic variations like mutations in the HLA-DRB1 gene are important in determining treatment response and vulnerability. Even if a lot has been accomplished, there are still obstacles to overcome in order to address genetic diversity and turn these findings into useful therapeutic applications.

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Owing to its abundant physiologically active compounds, this plant is often employed in traditional healing practices. Both its aerial and subterranean parts are used to address conditions such as dyspepsia, diabetes, hypertension, retinal damage, and swelling. Research has shown that flower extracts from Clitoria ternatea possess cytotoxic, antibacterial, antioxidant, anti-inflammatory, and antidiabetic effects that benefit human health. The flowers of Clitoria ternatea are both safe and effective, offering a diverse array of therapeutic applications, making them compelling candidates for functional food development. Clitoria has produced various primary and secondary metabolites, including clitorin, aparagitin, triterpenoids, anthocyanins, steroidal glycosides, and flavonols. This article reviews many of the pharmacological benefits of Clitoria ternatea, highlighting its hepatoprotective, cytotoxic, antiplatelet, anticonvulsant, antianxiety, antistress, antioxidant, anti-inflammatory, hyperlipidemic, antidiabetic, analgesic, and nootropic properties. Clitoria ternatea presents a potential source of therapeutic compounds for managing multiple health issues based on its established efficacy.

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clitoria ternatea ,antimicrobial ,Ayurveda ,Pharmacological properties, phytochemicals ,traditional system of medicine

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In the changing global context, the nature of education must also evolve. Keeping this need in mind, the New Education Policy 2020 has been formulated, incorporating the foundational principles of Indian education. In this context, the educational ideas provided by Kesri Singh Barhat have been fully implemented in the National Education Policy 2020. It can be said that the need for educational reforms experienced many years ago is still being felt today

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Technical Education, Value Education, Khalsa Land, Multidisciplinary, Holistic Education

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Mexican Argemone Linn, a plant widely distributed in tropical and subtropical areas globally, belongs to the Papaveraceae family. The Papaveraceae family, commonly referred to as the poppy family, includes 44 genera and approximately 760 species. This family holds significant importance from an ethnopharmacological perspective. It can be found growing in fields, alongside roads, and near water sources throughout India. The plant features leaves, roots, and flowers. Another designation for it is "Mexican Poppy." This article provides a comprehensive review of the chemistry and pharmacology of Argemone mexicana Linn. This species is recognized as one of the most crucial in traditional medical systems. Although alkaloids are the predominant compounds, the plant contains various other chemical constituents. While many plant parts have medicinal advantages, some may also present toxic effects. This article examines pharmacological, microscopical, morphological, and phytochemical research. Current findings related to the chemistry and pharmacology of this plant may serve as a valuable resource for researchers looking to pursue further studies in these domains.

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Argemone mexicana, Biological activity, Papaveraceae, Pharmaceutical potential, Phytochemical constituents, Traditional uses

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The rapid growth of online ticket reselling platforms has changed the face of the event ticketing industry, bringing about both opportunities for consumers and new challenges for equitable market access. Designed to provide a secondary marketplace for event tickets, platforms like StubHub, Ticketmaster Resale, and Vivid Seats have grown dramatically, bringing along with them complex dynamics around pricing, accessibility, and fraud. This review paper examines the present landscape of event ticket reselling, analyzing economic, technological, and regulatory factors that define this market. Important findings point out that even though reselling platforms improve the efficiency and flexibility of the market through dynamic pricing and real-time sales, such mechanisms often inflate prices and decrease accessibility for ordinary fans. Moreover, technologies like bots and automated purchasing systems increase artificial scarcity, raising ethical issues related to ticket availability and fair access. The paper also addresses the weaknesses of current anti- scalping laws and the fragmented approaches of the regions, which often fail to address cross-border resale practices.

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Dynamic Pricing , Ticket Fraud Prevention

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?????? ?? ??? ???? ??, ?? ???? ?? ???? ???? ???? ???? ??, ???? ?? ???? ???? ?????????? ???? ?? ??? ???? ???????? ??????? ?? ????? ???????? ??????? ?? ??? ???? ????????? ?????? ???? ???????????? ??????? ?? ???? ????? ?? ???-????? ?????? ????: ??? ?? ????? ?????? ???? ?? ??? ??????? ?? ??????? ?????????? ?? ????? ???? ??? ?????? ?????? ???? ??| ?? ?????? ??????? ????????? ????? ?? ????? ???? ?? ????????? ??????? ???? ??? ??????? ?? ????? ???? ??|????? ??? ???????? ???? ??????? ?? ??? ?????? ?? ?????? ????? ????????? ?????? ??????? ?? ??? ???? ?? ????? ???? ????: ??? (???? - ???????) ?? ?????? ????? ?????? ?????? ??| ???? - ??????? ?? ??????? ?? ?? ????? ???? ?? - ??????? ?? ????? ?? ??????? ??? ?? ????? ??? ???? ??| ?? ??????? ???? ????? ?? ??????? ??? ?? ????? ??? ?? ?? ???? ?? ??? ???? ????- ??????? ?? ??????? ??| ???????? ??????? ?? ???? ??????? ???? ??????? ?? ?????? ???? ?? ??? ??????????? ?????????? ?? ?????? ????? ???

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?????? -?????- ?????? ?? , ???? -??????? - ????? ?? ??????? ??? ?? ????? ??? ????? ??

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The design and development of Curcumin nanoparticles has attracted and established torrential research in nano formulation matrix. By appearance Curcumin is an orange crystalline powder which is derived or obtained from the herbs Curcumin Longa Linn (Zingiberaceae). The Curcumin is natural hydrophobic polyphenol compound which has proven to be a quintessential medicine in ancient China and many parts of Southeast and central Asia. Curcumin as a substance is vitally used in medicine and some food industry as it supplies many biological and pharmacological activities such as antioxidant, anti-inflammatory, anti-microbial, anti-illness and diseases but clinal application of this compound is limited due to its bioavailability, poor water solubility, fast metabolism and susceptibility to degradation in the alkaline medium. The most important methods to enhance the poor biopharmaceutical properties of Curcumin is to enhance aqueous solubility and bioavailability by using nanotechnology and nanoparticles having a small size in nanometer range. This review provides an overview of application and preparation of Curcumin nanoparticles including the advantages and limitations.

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Curcumin, Applications of Curcumin Nanoparticle, Methods of preparation of Curcumin Nanoparticles.

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Modern transportation systems rely on maintaining safe distances and detecting vehicles to help prevent accidents like rear-end collisions. This research showcases a specialized system that detects objects in real time and measures their distance, designed to work in challenging environments like foggy conditions. The system integrates an ultrasonic sensor for close-range obstacle alerts and a LiDAR module for accurate distance readings, supported by a real-time imaging component for enhanced visibility and awareness. Featuring an ultrasonic sensor that identifies objects within 25 cm, triggering an immediate alert, and a LiDAR sensor that measures distances up to 2 meters and displays the results on a 16x2 LCD, this system provides comprehensive obstacle detection. The imaging module, powered by an ESP32-CAM and processed by a Raspberry Pi, provides real-time video displayed on a 7- inch screen Experimental results validate the system's capability to detect obstacles and estimate distances, contributing to safer driving conditions. Future work will aim to enhance detection algorithms and adapt the system to broader environmental challenges.

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Vehicle detection, foggy conditions, ultrasonic sensor, LiDAR sensor, ESP32-CAM, real-time processing, collision prevention, distance measurement, advanced driver assistance systems (ADAS), safety enhancement.

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In today's fast-paced world, sustainable wellness necessitates a holistic approach that encompasses the mind, body, and spirit. Yoga, an ancient practice rooted in mindfulness and balance, offers a timeless pathway to achieve enduring well-being. This paper explores yoga's multidimensional benefits, from fostering physical strength and flexibility to enhancing mental clarity, emotional resilience, and spiritual connectedness. Supported by scientific evidence and traditional principles, yoga equips individuals with tools to cultivate balance, align with their values, and navigate life's challenges with grace. By integrating yoga into daily life, one can achieve sustainable wellness that nurtures personal and collective harmony.

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Yoga, Sustainable Wellness, Balance, Mindfulness, Holistic Health, Emotional Resilience, Spiritual Connection

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Creative Commons Attribution 4.0 and The Open Definition

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?????? ???? ?? ???? ?? ??????? ???????? ?? ????????? ????? ??????????? ???? ?? ??? ??????? ???????? ???? ??? ???? ???????, ??????, ?????????? ??? ??????? ????? ?? ??????? ???????? ?? ?? ????? ??? ???? ??? ???? ?? ???? ??? ?????? ???? ???? ??? ???? ???? ???? ??????? ??????? ????????? ?? ????? ?????? ?????? ?? ??????? ???????? ?? ?????, ???? ????? ??? ???? ??? ?????? ??? ??????? ??? ???????? ???? ???? ?? ?? ?? ?????? ??? ????, ????????? ??? ????? ?????? ????? ???? ??| ?????? ??????? ?? ?????????? ?????? ??? ???? ???????????? ?? ?????? ???? ???? ????????? ??? ??? ????????? ??? ???? ??? ?? ????? ?? ?????? ?????? ?? ??? ???????? ???? ?? ??? ???? ?? ????? ??? ?? ????????? ?????? ???? ?? ??? ??????? ?? ?????? ????? ??? ???? ?????? ????? ??? ?????? ???? ?? ??????? ??? ?? ????? ?????? ?? ??? ??? ?????????? ?? ??????? ??? ???? ?? ??? ?? ?????? ???? ??????? ??????? ?? ????????? ???? ??? ??? ???? ??? ?? ???? ??????? ?? ?? ?? ??? ??????? ?? ?????? ?? ?? ????? ??? ???? ??? ?? ?? ??? ?????? ?? ?? ??????? ????? ?? ???? ??? ????? ??? ??? ?????? ?? '??????' ?' ???-??????' ????? ????? ?? ????? ?? ??? ??

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??????- ?????(?????-?????? ?? ??????), ????????? ?????- ??????? ?????, ???????-, ???-?????? -???? |

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