Volume 12 | Issue 1 |

 Abstract

A manufacturing authorization holder is responsible for producing pharmaceuticals in a way that is appropriate for the intended purpose, complies with marketing authorization standards, and does not jeopardize patient safety by subpar quality, safety, or efficacy. Senior management bears the responsibility for achieving this quality target, which calls on the involvement and dedication of employees across numerous departments and levels of the organization, as well as suppliers and distributors. To consistently achieve the quality objective, a thorough system of quality assurance that incorporates good manufacturing practices--and, by extension, quality C and quality risk management--must be created and implemented appropriately. Its efficacy ought to be tracked and thoroughly documented. Every component of the quality assurance systems needs to have enough staff, appropriate and sufficient space, equipment, and facilities, as well as knowledgeable individuals. The holder of the manufacturing authorization for the authorized person is subject to additional legal obligations.

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 Keywords

Good Manufacturing Practices, pharmaceutical industry, quality, regulatory authorities, security and effectiveness

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Creative Commons Attribution 4.0 and The Open Definition

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Creative Commons Attribution 4.0 and The Open Definition

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This study extensively investigates the effectiveness and adoption of robo-advisory systems in India's emerging wealth management industry. Robo-advisory has become a technologically innovative solution for investment guidance and financial management. In India, which is experiencing rapid expansion, understanding the changing dynamics of robo-advisory and its effect on the behavior of investors and their returns becomes crucial. The study uses an integrated approach that blends an analysis of the adoption rate and performance metrics of robo-advisory platforms and a qualitative analysis of investors' perceptions and preferences. The research employs a variety of data sources to examine trends in historical adoption along with platform-specific data and feedback from investors.

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Robo-advisory, wealth management, adoption, effectiveness, investor behavior, investment returns, India.

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Right to live a free and dignified life is one of the most important basic principles of human Rights. Every person is entitled to live a life on their own way with no unfair interference from others. A successful democracy can only be one that guarantees its citizens the right to protect their own life and liberty. In India, the protection of Life and Personal Liberty is a Fundamental Right granted to every citizen under Part III of the Constitution of India. Fundamental Rights represent the foundational values cherished by the people and are granted against actions of the state. It means that no act of any state authority can violate any such right of a citizen except according to the procedure established by law. The relevant provision of the constitution reads under: "No person shall be deprived of his life or personal liberty except according to the procedure established by law" and this is known as the Right to Life and Personal Liberty. The present Article emphasis on the prohibit on or the encroachment upon a person's right to life and personal liberty against the state. The state refers to all entities having statutory authority like the Government and Parliament at the Central and State level, local authorities etc. So, the violation of the right by private entities is not within its purview. The term 'life' and 'personal liberty' encompasses a wide variety of rights of the people. which is a result of the evolution in the interpretation of Article 21 of Indian Constitution by the courts. The present paper also examines the various aspects of the present Fundamental Right.

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 Keywords

Life, Personal liberty, Law, deprived, Right, Article21

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Attention has been drawn to Speech Emotion Detection (SED) due to its crucial role in understanding human emotional states through speech signals. This extensive survey paper explores the historical progression, current methodologies, and prospects of SED. It explores early approaches, emphasizes the emergence of advanced machine-learning techniques, and examines the challenges in accurately discerning emotions from speech. The survey provides an in-depth analysis of notable datasets, evaluation metrics, and cutting-edge models used in SED. Additionally, it outlines potential improvements and upcoming trends that are poised to shape the future landscape of this field. This survey consolidates a vast amount of information, offering insights into the past, present, and promising directions for advancing SED.

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 Keywords

Speech Emotion Detection, Emotion Recognition, Speech Signals, Machine Learning Techniques, Emotion Discernment, Datasets, Evaluation Metrics, Natural Language Processing, Audio Processing, Human Emotional States

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BACKGROUND: Hypercholesterolemia is a strong predictor of coronary Heart Disease mortality. The prevalence of Coronary Artery Disease (CAD) is known to be very high both among migrant Asian Indians and also among people within the Indian sub continent. Evidence suggested that high - fiber diets in accordance with American Heart Association (AHA) reduces serum cholesterol by 11 - 32 percent. Many studies have shown that soluble fibre beta-glucan present in oats have a beneficial effect in reducing cholesterol. So, the study was carried out with the following objectives. OBJECTIVES: to study the comparative effect of two different oat bran recipes, namely oat bran biscuits and oat bran porridge on hypercholesterolemic subjects and to check whether there is an effect in the food processing method employed. DESIGN: Prospective design with purposive sampling technique was employed for the study. 12 hypercholesterolemic subjects were selected belonging to the age group of 40-55 years. Baseline information of the selected subjects were obtained using an interview schedule which includes information regarding age, sex, physical activity pattern, personal habits, dietary habits, anthropometric details such as weight, BMI, Waist circumference. The study consisted of two groups, each group consisting of six samples respectively in accordance with the type of supplementation namely oat bran biscuits and oat bran porridge. RESULTS: Significant difference was found to be observed in total cholesterol levels among both the group of subjects (at 5 percent and 1 percent significance levels). LDL was not found to be significant in experimental group 1 subjects whereas in experimental group 2 it showed significant results. Similarly HDL cholesterol also showed significant results in group 2. After comparing each parameter within the 2 groups the results showed that there was no significant difference in total cholesterol, LDL, HDL, triglycerides, VLDL and their ratios between both the groups. CONCLUSION: Comparison of oat bran biscuits and oat bran porridge supplementation proved that there is no difference in food processing method, with both the forms showing similar effects on hypercholesterolemia. Fibre supplementation in any form can be helpful for reducing the risk of complications and improving the lifespan from dreaded diseases like diabetes mellitus and cardiovascular diseases.

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Oats, soluble fibre, hypocholesterolemia

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: In the literature, environmental issues are covered in greater detail. Feminist research integrates ecology and makes the connection between the deterioration of nature and the subjugation of women. In the topic of ecofeminism, feminist ideas and opinions are affirmed from a feminine perspective. It also calls into question the egalitarian perspective of human nature and the male-dominated society. The current paper's goal is to examine the ecofeminist elements in Gita Mehta's A Rivers Sutra. Ecofeminism frequently demonstrates the intimate connection between women's enslavement and the destruction of nature. In one sense, it is evident that humans rule nature, and in a similar vein, men dominate women. However, ecofeminism advocates for treating all women with dignity and equality in society. The research paper's goal is to examine how women and nature are related to politics, culture, the economy, and literature.

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Gita Mehta, A River Sutra, feminism, ecofeminism, gender, ecology etc.

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This study investigated the factors influencing saving and investment behaviour among Dakshina Kannada residents, aiming to identify key determinants and potential interventions to improve financial well-being. A quantitative survey approach was employed, collecting data from 100 Residents through a structured questionnaire. Principal component analysis and hypothesis testing were used to analyze the relationships between financial goals, saving/investment rates, perceived barriers, instrument preferences, and socio-demographic variables. Five distinct factors were identified: financial goals, barriers to saving, preferred instrument characteristics, financial knowledge, and financial institution access. Higher saving/investment rates were associated with specific goals like retirement planning, and negatively impacted by knowledge gaps and limited access to financial services. Income showed no direct effect, but digitalization positively influenced the adoption of modern saving/investment instruments. Financial literacy programs and improved access to financial institutions are crucial in overcoming barriers and boosting saving/investment rates, especially among low-income individuals. Tailored interventions addressing specific financial goals and knowledge gaps may further enhance financial well-being. This study provides a comprehensive understanding of saving/investment determinants in the Indian context, offering valuable insights for policymakers and financial institutions to develop targeted interventions for promoting financial inclusion and long-term financial security. Additionally, the identification of five distinct factors contributes to the theoretical understanding of saving behaviour and can inform future research in diverse economies.

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Saving and investment behaviour, Financial well-being in India, Financial literacy and barriers, Digitalization and financial inclusion, Multi-faceted determinants of saving

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von Willebrand's disease (vWD) arises from abnormalities in von Willebrand factor (vWF), an adhesive glycoprotein uniquely involved in key aspects of both primary and secondary hemostasis. The current classification distinguishes disorders arising from partial (type 1) or complete (type 3) deficiencies and from qualitative defects (type 2). Type 2 vWD is further divided into four subtypes (A, B, N, and M), reflecting distinct classes of functional abnormalities. Mis-sense mutations account for most of type 2 vWD, whereas major disruptions in the vWF gene produce type 3 variants. The molecular basis of type 1 vWD is largely undefined. The laboratory diagnosis of vWD and its several variants is made on the basis of immunologic and functional studies of vWF, factor VIII levels, and specialized electrophoretic analysis (multimer gels). The mainstay of therapy for most patients with vWD in desmopressin, a pharmacologic agent that stimulates the release of endogenous pools of vWF. Cryoprecipitate and selected factor VIII concentrates are useful sources of exogenous vWF for the treatment of patients unresponsive to this desmopressin

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 Keywords

von Willebrand disease, Willebrand factor, glycoprotein, hemostasis, Mis-sense mutations, gene, factor-VIII, desmopressin, bleeding disorder

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Creative Commons Attribution 4.0 and The Open Definition

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The COVID-19 pandemic has profoundly impacted India's GDP, causing significant disruptions across various sectors of the economy. This abstract summarizes the key points regarding the influence of covid19 on india's GDP.

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 Keywords

Covid19, Gross Domestic product (GDP), Economy.

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Creative Commons Attribution 4.0 and The Open Definition