Volume 8 | Issue 10 |

 Abstract

The Current investigation deals with safety, efficacy and quick onset of action of existing drug molecule through novel concepts of drug delivery. Orally disintegrating tablets of Rizatriptan benzoate were prepared by direct compression method to provide faster relief from pain to migraine sufferers. About eight formulations for the present study were carried out based on 32 factorial design technique for each set of superdisintegrants. Psyllium mucilage, Musa paradisiaca were used as superdisintegrants, while microcrystalline cellulose was used as diluent. The prepared batches of tablets were evaluated for weight variation, hardness, friability, wetting time, invitro dispersion time, drug content and invitro dissolution studies. The formulation containing combination of Psyllium mucilage, Musa paradisiaca showed rapid invitro dispersion time as compared to other synthetic & natural formulations.

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Orally disintegrating tablets, Superdisintegrants, Rizatriptan benzoate, Factorial design technique, Direct Compression, UV spectrophotometer.

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The aim of the present study was to evaluate the antimicrobial activities of aqueous extract of leaf of Argemonemexicanaand root of Alangiumsalvifolium.The aqueous leaf extracts of Argemonemexicanawere subjected to qualitative tests, by screening of phytoconstituents that present in the extracts, and to quantitative tests by evaluation of antimicrobial activity using well agar diffusion method. The aqueous root extract of Alangiumsalvifoliumwas prepared and were tested on Gram positive bacteria. Agar cup plate test was used to determine the sensitivity of the tested samples while the well microdilution was used to determine the minimum inhibitory concentration. The drug extract were extracted using solvent extraction by soxhlet apparatus, different concentration of these extract were prepared ranging 0.1-1.0mg/ml and antimicrobial activity is performed on Staphylococcus aureus (gram positive) bacteria using nutrient agar medium as broth. It was found that the above drug combination (Argemonemexicana, Alangiumsalvifolium)on the respective gram positive bacteria (Staphylococcus aureus) was showing significant antimicrobial activity . The minimum inhibitory concentration of combination of both drugs was found to be 6.1mm for the concentration of 4:6 mg/ml for both drugs. The overall results of this study indicates that the extract from both the drugs have interesting antimicrobial and potential free radical scavenging activity for treatment of psoriasis disease.

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The aim of the present study was to evaluate the antimicrobial activities of aqueous extract of leaf of Argemonemexicanaand root of Alangiumsalvifolium.The aqueous leaf extracts of Argemonemexicanawere subjected to qualitative tests, by screening of phytoconstituents that present in the extracts, and to quantitative tests by evaluation of antimicrobial activity using well agar diffusion method. The aqueous root extract of Alangiumsalvifoliumwas prepared and were tested on Gram positive bacteria.

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World is endowed with a rich wealth of medicinal plants and they have been always principle form of medicine. Traditionally mature leaf decoction of Leucas biflora is used as eye drop twice a day in case of conjunctivitis. The mature leaves ground with leaves of Centella asiatica in a ratio of 2:1 and juice extracted from this mixture is applied directly to stop instance of bleeding from nose. Four to five leaves are also prescribed to chew with a leaf of Piper betel for the women who suffering from white discharge. The leaves of Leucas biflora was collected, identified and authenticated. The dried leaves of L. biflora pulverized to make coarse powder and decoction prepared and evaporated to get a dry residue. Aqueous extract have been standardized by evaluating organoleptic characters, macroscopically characters, physicochemical properties, screening of phytochemical constituents, total flavonoids content. Phytochemical screening shows the presence of carbohydrates, glycosides, flavonoids, tannins, Saponins and steroids. Quantitative determination of total flavonoids content in L. biflora aqueous extract was carried out using aluminium chloride colorimetric method. Quercetin was used as standard for calibration of flavonoids. The results indicate that the L. biflora plant is the rich source of high valve of phytochemical compounds.

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Leucas biflora, nasal bleeding, standardization, physicochemical characterization, Total flavonoid contents.

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 Abstract

MAHILAO PAR ATYACHAR EK SAMAJIK SAMSYA

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MAHILAO PAR ATYACHAR EK SAMAJIK SAMSYA

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Continuous and comprehensive evaluation (CCE) helps in identification of areas for which the student has aptitude and interests. As a result, it helps in focusing efforts in identifying the areas where changes in value systems and attitudes are required. CCE helps the individual students to make decisions regarding the future pertaining to the courses, choice of subjects and carriers to be chosen in future life. CCE helps in generating appropriate information/reports pertaining to the progress of the students with regard to scholastic as well as co-scholastic areas and thus help in predicting the future performance and success of the learner. Continuous evaluation helps the evaluator to diagnose the weaknesses of the students and permits the teacher to ascertain the weaknesses and strengths of the individual learner along with his/ her needs. CCE provides an instant and immediate feedback to the teacher who can then come to a conclusion if there exists a need to revisit a particular concept or unit and teach the same to a few individual students who are in need of remedial instruction or to the entire class. Objectives of the study are to find out the significant differences in the awareness of teachers on continuous and comprehensive evaluation in secondary schools due to variations in their gender and years of experience. The method that has been adopted by the investigator in the present research study is the survey method. The total number of statements in the questionnaire was 66 with 8 dimensions. The findings of the study will draw the attention of all policy planners, school administration and stakeholders to take necessary steps for smooth functioning of CCE in secondary schools. In the light of findings of the study few recommendations are made for effective implementation of CCE.

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Continuous and comprehensive evaluation (CCE), scholastic, co-scholastic

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A language consists of symbols that convey meaning, plus rules for combining those symbols, that can be used to generate an infinite variety of messages. Learning disabilities make a reference to a variety of disorders that affect the acquisition, understanding, retention, organizing or use of verbal or non-verbal information. These disorders are the result of impairments in connection with one or more psychological process relating to learning in combination with other average abilities which are essential for listening and thinking. Learning abilities are specific and are not global impairments and as a result, they are distinct from the intellectual disabilities. A teacher should be endowed with certain professional competencies for performing the task that is assigned to him successfully. He should have a consummate knowledge regarding the curriculum that is specified for teaching. Objectives of the study were to find out the significant differences in the competencies required on various aspects of Telugu language learning difficulties in children by the primary school teachers due to variation in their gender and years of experience.As a result, it can be understood that there is vast scope for providing orientation, pre-service and in-service training programmes to the teachers of the primary schools for them to acquire competence to greater extent and similarly, the government must make efforts to incorporate content pertaining to Telugu learning difficulties in teacher training programmes.

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Learning disabilities, Telugu language learning difficulties, competencies of teachers, etc.

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Buccal mucosa is an attractive route for systemic delivery of drugs and it is relatively permeable with a rich blood supply Rabeprazole Sodium is a Proton Pump Inhibitor (PPI). It is mostly prescribed in active duodenal ulcers, gastric ulcers, Zollinger-Ellison syndrome, gastroesophageal reflux disease, and erosive esophagitis. Rabeprazole sodium having the highest acid inhibiting effect among other PPI and H2- antagonist. However, Drug having very short half-life (1.5 hr) and low bioavailability (52%). Further, in the marketed formulation various dosage form (granules, tablets and pellets are available) which is enteric coated due to degradation in the gastric and therefore onset of action delayed..In this present study, an attempt has been made to develop a Rabeprazole sodium buccal adhesive tablet to avoid the gastric degradation and first pass metabolism. Two prime considerations in the design of a buccal adhesive tablet. One is to attach firmly to the buccal mucosa and other in case of rabeprazole is the stability of Rabeprazole sodium in human saliva, since it is very unstable in acidic and neutral media. There are various bioadhesive polymer present which are polyacrylic acid derivative such as polycarbophil and other polymer like sodium alginate, Chitosan, HPC, HEC, Sodium CMC, Polyox, HPMC etc. In the Present work, Gantrenz and HPMC selected for the adhesive dosage form. Gantrenz MS 955 is Polyacrylic acid derivative and having both anion and cation.

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FORMULATION AND EVALUATION OF BUCCAL TABLET RABEPRAZOLE SODIUM

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We as a whole realize that utilization of ICT spread over in the data age. Libraries are atomizing their housekeeping activities. The paper intends to feature client's recognitions on library robotization. It does exclude perspectives like how to do robotization, what programming is utilized for the mechanization and so forth. The goal of the examination is to discover client's mindfulness about library computerization. Effect of computerization of library housekeeping exercises on a use of the library and scholastic work of clients. Discover advantages and disadvantages of library robotization and to get clients proposals for additional improvement. Information have been gathered from the 100 clients of scholarly library with the assistance of electronic poll. It is examined with the assistance of tables and charts. It is found from investigation of the information that clients know about the computerized arrangement of a library, and they are happy with the speedy assistance of the library after robotization. The end drawn is clients are adjusted with the robotized library sources and administrations like webopac and due book update. They know about the distinctive library computerization programming. They said that with the robotization their working limit is increment and they will finish their undertaking in less time.

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ICT, Academic Library, Computerization. Robotization.

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Abstract Literally �Meta� means �beyond� and �physics� means �physical nature�. It was Dryden who first used the word, �Metaphysical� in connection with Donne�s poetry. This research paper highlights John Donne as a Metaphysical Poet. This paper shows that really John Donne was a unique poet in his writing style of metaphysical poetry. There are many remarkable poems �The Flea�, �Sweetest Love I do not go�, �The Ecstasy�, �Death Be Not Proud�, �The Sun Rising� etc. by the genius of John Donne which prove him a metaphysical Poet. ?

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John Donne,metaphysical poet, his writing style ,wit and humour, imagery and uncommon references and comparisons and his remarkable poems

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Our point in the current paper is to examine a "psychological view" of reading comprehension, with specific consideration regarding research discoveries that can possibly improve our comprehension of troubles in reading comprehension. We give an outline of how explicit causes of troubles in surmising making, chief capacities, and consideration distribution impact reading perception cycles and results and may prompt reading comprehension problems. At last, we talk about how the thought of these expected causes of trouble have handy ramifications for the plan and choice of instructional materials.

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Reading ,Constructive,Strategic

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