Volume 12 | Issue 10 |

 Abstract

Active Pharmaceutical Ingredients (APIs) are the core components of pharmaceutical products that directly contribute to their therapeutic effects. The development, synthesis, and formulation of APIs are pivotal in ensuring the efficacy, safety, and quality of medicinal products. With the growing emphasis on personalized medicine, the role of APIs has evolved significantly, transitioning from a generalized therapeutic approach to one that is tailored to individual genetic, phenotypic, and environmental profiles. Personalized medicine relies on pharmacogenomics to optimize drug selection and dosing, ensuring that patients receive the most effective treatment while minimizing adverse effects. This review aims to explore the current state of API development in the context of personalized medicine, highlighting advances in genetic testing, pharmacokinetic and pharmacodynamic considerations, and regulatory challenges. Furthermore, it addresses the ethical, economic, and technological implications of personalized APIs, including the use of AI-driven drug discovery and the integration of companion diagnostics. As the pharmaceutical industry continues to innovate, personalized APIs are expected to play a key role in the future of precision medicine, offering the potential for improved patient outcomes and more efficient drug therapies.

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 Keywords

Personalised, Medicine Drug formulation, Drug delivery system, Precision medicine, Bio pharmaceuticals, Pharmacokinetics, Pharmacodynamics, Companion diagnostics, Targeted therapy, Genetic biomekar, Biomekar's discovery, Genetic polymorphism, Drug metabolism, Drug interaction, Pharmacogenetic variability.

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

A comprehensive look at the tools and methods used to create a thesaurus is provided in this paper. Its goal is to locate published works on the construction of thesauruses. This study employs a method known as a systematic review. Since 1960, a variety of information sources have been used to search the literature. 24 of the 152 research papers, conference papers, and book chapters were chosen based on specific inclusion and exclusion criteria. The study led to the discovery of previously unpublished research on the thesaurus-building tools and methods. Thesaurus structure and relationships, the role or significance of classification schemes in the construction of thesaurus, and other similar topics reviewed here are those used by various thesaurus developers in various fields. In the context of the creation of a thesaurus, the methodology and guidelines utilized in its construction are also examined in this study.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

thesaurus, thesaurus construction, classification, thesaurus relationships, descriptors, natural language, subject headings, storage and retrieval, Systematic literature review.

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

water is a vital element for life

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wqi

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Creative Commons Attribution 4.0 and The Open Definition

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Creative Commons Attribution 4.0 and The Open Definition

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Keywords: Nursing, Profession, Leadership skills, Staff nurses, Hospitals.

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Creative Commons Attribution 4.0 and The Open Definition

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Creative Commons Attribution 4.0 and The Open Definition

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Diagride structural system, hexa Gride, Etabs, RSM , static loading, Dynamic Loading,

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Creative Commons Attribution 4.0 and The Open Definition

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Plants are the primary source of many medicines, and they are crucial to human and plant health in particular. Many plants and herbs are well known for their therapeutic and curative properties. The use of different plants as medicinal plants in the healthcare system has become crucial everywhere in the world. MPs (medicinal plants) are very important in the medical field because of their greater adaptability and compatibility with the human body, which means they have fewer side effects and are more widely accepted. It has been shown that the majority of commonly used medications contain plant extracts as a primary ingredient. As active ingredients, many of them contain bioactive components that are extracted from plants. The medicinal properties of MPs have been uncovered through a number of studies through the investigation of conventional and therapeutic treatments. The most widely used medications that are believed to be derived from PEs (plant extracts) include aspirin, digoxin, pilocarpine, quinidine, physostigmine, morphine, reserpine, ephedrine, taxol, colchicine, vincristine, aspirin, and tubocurarine. It is impossible to overlook MPs' enormous significance anywhere in the world. Certain secondary compounds derived from plants, like those found in pawpaw, mango, citrus, and Emilia sonchifolia, may be highly effective against parasites and infections.(1, 2)

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TRADITIONAL AND MODERN PHARMACOLOGICAL APPLICATIONS OF EMILIA SONCHIFOLIA: AN INTEGRATED REVIEW

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Creative Commons Attribution 4.0 and The Open Definition

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In this high-tech era, technology has made it possible that everyone can live a comfortable life. But somehow the physically challenged people need to depend upon others in their daily life which ultimately makes them less confident in an unfamiliar environment. But nowadays the explosion of innovative technology provides many opportunities for them to live confidently without feeling as a burden. So, in this project, an intelligent device is represented for visually challenged people to guide them to reach their destination place safely without facing any difficulties. It consists of Arduino controller, voice module along with Ultrasonic sensor. Blind people find it difficult to move in this world as they get distracted by the obstacles, they may even get lost. So in the proposed system the above mentioned cases are taken into consideration and implementation is provided. In order to help the blind people for detecting object the proposed system make use of ultrasonic sensors to track the person. The system makes use of voice module and speaker to find the objects. The main objective of this project is to reduce the cost and to provide a better solution for the visually impaired

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Blind stick, ultrasonic sensor, Obstacle recognition, Arduino

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Creative Commons Attribution 4.0 and The Open Definition

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The feminist perspective on Shakespeare's Othello has gained increasing attention in modern literary discourse, with a particular focus on the character of Emilia. Often overshadowed by more prominent figures like Desdemona, Emilia's role in the play is crucial in understanding the complex dynamics of gender, power, and autonomy in the Elizabethan era. This paper aims to re examine Emilia's character through a feminist lens, emphasizing her transformation from a subservient wife to a vocal critic of the patriarchy. By analyzing her interactions with Iago and Desdemona, as well as her final, bold confrontation with her husband, the paper highlights Emilia's agency and underscores her pivotal role in Othello. The exploration of Emilia's defiance against the male-dominated society presents her as a proto-feminist character, whose voice, though silenced tragically at the end, resonates as an early challenge to patriarchal norms.

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 Keywords

Emilia, Othello, feminist analysis, gender roles, patriarchy, marriage dynamics, female agency, loyalty vs. morality, feminist resistance, female empowerment, power dynamics, double standards, women's rights, Shakespeare's women, Iago, Desdemona, tragic heroine, female voice, social norms.

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Creative Commons Attribution 4.0 and The Open Definition

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In Ramakrishna, Vivekananda and Dayananda, the best of Hinduism was blended with the modern spirit of humanism which was flooding India of the nineteenth century. A new inspiration was abroad and under its urge the medieval molds, already weakened, Degan to break down. The individual realized the significance of the self as well as a new responsibility towards society.

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WOMEN'S STRUGGLE FACED IN THE INDIAN SOCIETY

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Forensic science plays an vital role in the criminal justice system. Criminal investigations are performed through technical assistance to decide whether a crime has been committed, when how and by whom. In many cases of death, the determination of time, cause and form of death are important. The postmortem examination report becomes pivotal as evidence on which the entire case is dependent. As an evidentiary rule, the judicial approach is tented towards accepting medical evidence only in case of consistency with the prosecution case. The aim of this article's post-mortem examinations in the confirmation, clarification, and importunate of the diagnoses , as well as the evidentiary evolution of post- mortem report in criminal justice system. The paper throws highlight upon the circumstances in which the post mortem examination report shall be considered as evidence in court and judicial approach is critically assessed. The value of the post mortem examination in court proceedings has been determined through this research paper. The aim of the paper has to death of manner ,cause of death and the evidentiary evaluation of autopsy and as well as the approaches of the Judicial regarding the report of the autopsy. Forensic Science as pivotal role in the recent era in Criminal investigation and judicial system.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Medico-legal study ,Forensic evidence ,Autopsy, Criminal Investigation

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Creative Commons Attribution 4.0 and The Open Definition