IJCRT Peer-Reviewed (Refereed) Journal as Per New UGC Rules.
ISSN Approved Journal No: 2320-2882 | Impact factor: 7.97 | ESTD Year: 2013
Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 7.97 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(CrossRef DOI)
| IJCRT Journal front page | IJCRT Journal Back Page |
Paper Title: An AI-Driven Resume Parsing and Ranking System Using Natural Language Processing For Automated Talent Shortlisting
Author Name(s): Gayatri Yeravadekar, Yug Jain, Prathamesh Yewale, Yug Vyas, Shritej Zad
Published Paper ID: - IJCRT2512232
Register Paper ID - 298431
Publisher Journal Name: IJPUBLICATION, IJCRT
DOI Member ID: 10.6084/m9.doi.one.IJCRT2512232 and DOI :
Author Country : Indian Author, India, 411007 , Pune, 411007 , | Research Area: Science and Technology Published Paper URL: http://ijcrt.org/viewfull.php?&p_id=IJCRT2512232 Published Paper PDF: download.php?file=IJCRT2512232 Published Paper PDF: http://www.ijcrt.org/papers/IJCRT2512232.pdf
Title: AN AI-DRIVEN RESUME PARSING AND RANKING SYSTEM USING NATURAL LANGUAGE PROCESSING FOR AUTOMATED TALENT SHORTLISTING
DOI (Digital Object Identifier) :
Pubished in Volume: 13 | Issue: 12 | Year: December 2025
Publisher Name : IJCRT | www.ijcrt.org | ISSN : 2320-2882
Subject Area: Science and Technology
Author type: Indian Author
Pubished in Volume: 13
Issue: 12
Pages: b946-b955
Year: December 2025
Downloads: 219
E-ISSN Number: 2320-2882
The existing system for screening and ranking resumes is done manually in which recruiters rank resumes based on their company policies. It is not only time-consuming but also prone to human error and often influenced by biased opinions. Automated-resume screening has grown in popularity as it is more efficient and accurate. The main goal of this system is to help recruiters and job-seekers to recruit and get recruited, respectively. Not only we develop our system that does what traditional AI-based resume rankers do but also gives valuable insights and detailed analysis of our users that could improve their resumes ultimately making them more deserving candidates for that job position.
Licence: creative commons attribution 4.0
Intelligence, Machine Learning, Resume Parse, Weighting Filter, RegEx, NLP
Paper Title: Construction and Development of a Scientific Knowledge and Aptitude Test
Author Name(s): Dr. Chandra Mukherjee
Published Paper ID: - IJCRT2512231
Register Paper ID - 298418
Publisher Journal Name: IJPUBLICATION, IJCRT
DOI Member ID: 10.6084/m9.doi.one.IJCRT2512231 and DOI : https://doi.org/10.56975/ijcrt.v13i12.298418
Author Country : Indian Author, India, 700078 , Kokata, 700078 , | Research Area: Medical Science All Published Paper URL: http://ijcrt.org/viewfull.php?&p_id=IJCRT2512231 Published Paper PDF: download.php?file=IJCRT2512231 Published Paper PDF: http://www.ijcrt.org/papers/IJCRT2512231.pdf
Title: CONSTRUCTION AND DEVELOPMENT OF A SCIENTIFIC KNOWLEDGE AND APTITUDE TEST
DOI (Digital Object Identifier) : https://doi.org/10.56975/ijcrt.v13i12.298418
Pubished in Volume: 13 | Issue: 12 | Year: December 2025
Publisher Name : IJCRT | www.ijcrt.org | ISSN : 2320-2882
Subject Area: Medical Science All
Author type: Indian Author
Pubished in Volume: 13
Issue: 12
Pages: b935-b945
Year: December 2025
Downloads: 227
E-ISSN Number: 2320-2882
The objective of the study is to develop or construct a Scientific Knowledge and Aptitude Test. 200 items were initially selected with 60 items from Life Science, 80 items from Physical Science and 60 items from Mathematics. A draft test was administered on 150 boys and girls of Class IX and 50 boys and girls of class X English Medium Secondary Schools of Kolkata. The major purpose of the study was to find out the difficulty value and discriminating power of the items by the method of item analysis, Where N = 150, boys and girls of Class Ix, difficulty value has ranged between .12666 to .79333 and discriminating power between .0118824 and .902439. The difficulty values were determined in terms of the samples passing an item and discriminating power was determined as per difference of such proportion between the top and bottom 27% of the sample groups. 100 items were selected for the final item pool and was administered on 99 boys and 127 grills (N=226 of the standardization sample. The range of Difficulty value and discriminating power of the final 100 item pool was 0.1681415 to 0.7654867 and 0.0044642 to 0.7951388 respectively. From the range of difficulty value and discriminating power of the final 100 items, it can be revealed that the items are spreaded equally on both the sides of .50 the items included was from the easiest to the most difficult the sampling was purposive.
Licence: creative commons attribution 4.0
Aptitude, Difficulty value, Discriminating power, Scientific knowledge,
Paper Title: Analysis of Burakovsky – Preston Model For The Grüneisen Parameter of Geophysical Minerals
Author Name(s): K. Sunil, K. Dharmendra
Published Paper ID: - IJCRT2512230
Register Paper ID - 298445
Publisher Journal Name: IJPUBLICATION, IJCRT
DOI Member ID: 10.6084/m9.doi.one.IJCRT2512230 and DOI : https://doi.org/10.56975/ijcrt.v13i12.298445
Author Country : Indian Author, INDIA, 282002 , Agra, 282002 , | Research Area: Physics All Published Paper URL: http://ijcrt.org/viewfull.php?&p_id=IJCRT2512230 Published Paper PDF: download.php?file=IJCRT2512230 Published Paper PDF: http://www.ijcrt.org/papers/IJCRT2512230.pdf
Title: ANALYSIS OF BURAKOVSKY – PRESTON MODEL FOR THE GRüNEISEN PARAMETER OF GEOPHYSICAL MINERALS
DOI (Digital Object Identifier) : https://doi.org/10.56975/ijcrt.v13i12.298445
Pubished in Volume: 13 | Issue: 12 | Year: December 2025
Publisher Name : IJCRT | www.ijcrt.org | ISSN : 2320-2882
Subject Area: Physics All
Author type: Indian Author
Pubished in Volume: 13
Issue: 12
Pages: b928-b934
Year: December 2025
Downloads: 244
E-ISSN Number: 2320-2882
We present an analysis of the volume dependence of Grüneisen parameter and its higher order derivatives q and ƛ for five geophysical minerals viz. MgO, CaO, MgSiO3 , CaSiO3 and Pyrope garnet ( Mg3Al2Si3O12). The Burakovsky – Preston model has been used for representing gamma as a function of volume for the entire range of compressions. We have determined and reported values of γ, q and ƛ at different values of volume compressions. Values of these thermoelastic parameters ( γ, q and ƛ) have been transformed to the corresponding pressures using the Holzapfel equation of state for the minerals under study.
Licence: creative commons attribution 4.0
Grüneisen parameter ; Higher order derivatives; Equation of State ; Burakovsky – Preston model; Geophysical minerals.
Paper Title: Early Prediction of Eye Diseases using Machine Learning models and Ensemble techniques
Author Name(s): Madhab Paul Choudhury, Jagannibas Paul Choudhury
Published Paper ID: - IJCRT2512229
Register Paper ID - 298151
Publisher Journal Name: IJPUBLICATION, IJCRT
DOI Member ID: 10.6084/m9.doi.one.IJCRT2512229 and DOI :
Author Country : Indian Author, India, - , -, - , | Research Area: Science and Technology Published Paper URL: http://ijcrt.org/viewfull.php?&p_id=IJCRT2512229 Published Paper PDF: download.php?file=IJCRT2512229 Published Paper PDF: http://www.ijcrt.org/papers/IJCRT2512229.pdf
Title: EARLY PREDICTION OF EYE DISEASES USING MACHINE LEARNING MODELS AND ENSEMBLE TECHNIQUES
DOI (Digital Object Identifier) :
Pubished in Volume: 13 | Issue: 12 | Year: December 2025
Publisher Name : IJCRT | www.ijcrt.org | ISSN : 2320-2882
Subject Area: Science and Technology
Author type: Indian Author
Pubished in Volume: 13
Issue: 12
Pages: b912-b927
Year: December 2025
Downloads: 188
E-ISSN Number: 2320-2882
Artificial Intelligence (AI) has changed something so that it becomes much better in various aspects of our lives, offering solutions to numerous problems and bridging gaps between reality and business. Within the domain of AI, emerging technologies such as machine learning and deep learning models have played an important role in transforming the way so that we can analyse data, make decisions, and can take action or give attention to difficult situations or problems, with an objective to understand them to find solutions. Liver disease encompasses a wide range of conditions that impair the liver's ability to function properly, leading to serious health issues. Risk factors for liver disease include viral infections (e.g., hepatitis B and C), excessive alcohol consumption, obesity, metabolic disorders, and genetic predisposition. Symptoms vary depending on the disease's severity but commonly include fatigue, jaundice, abdominal pain, and swelling. If the lever disease can be detected in early life, certain preventive measures can be taken so that the patient can recover from lever disease and can enjoy a real and happy life. Here machine learning models and ensemble methods of machine learning models have been applied for selecting a proper model for prediction of lever disease of the person. Under machine learning models Random forest, decision tree, gradient boosting, KNN(K nearest neighbour), logistic regression have been used. Under ensemble methods, voting classifier using maximum voting, average voting, Blending, Bagging and boosting, stacking of models have been used.
Licence: creative commons attribution 4.0
machine learning models, Random forest, decision tree, gradient boosting, KNN(K nearest neighbor), Ensemble techniques, voting classifier using maximum voting, average voting, Blending, Bagging and boosting.
Paper Title: Role Of Bioactive Phytocompounds Against Multidrug-Resistant Microorganism
Author Name(s): Ankit kumar, Sagar Kumar, Arvind Kumar, Divyanshu yadav, Rohit pal , Suraj kannaujiya
Published Paper ID: - IJCRT2512228
Register Paper ID - 298438
Publisher Journal Name: IJPUBLICATION, IJCRT
DOI Member ID: 10.6084/m9.doi.one.IJCRT2512228 and DOI :
Author Country : Indian Author, India, 222001 , jaunpur, 222001 , | Research Area: Health Science All Published Paper URL: http://ijcrt.org/viewfull.php?&p_id=IJCRT2512228 Published Paper PDF: download.php?file=IJCRT2512228 Published Paper PDF: http://www.ijcrt.org/papers/IJCRT2512228.pdf
Title: ROLE OF BIOACTIVE PHYTOCOMPOUNDS AGAINST MULTIDRUG-RESISTANT MICROORGANISM
DOI (Digital Object Identifier) :
Pubished in Volume: 13 | Issue: 12 | Year: December 2025
Publisher Name : IJCRT | www.ijcrt.org | ISSN : 2320-2882
Subject Area: Health Science All
Author type: Indian Author
Pubished in Volume: 13
Issue: 12
Pages: b901-b911
Year: December 2025
Downloads: 153
E-ISSN Number: 2320-2882
The rise of multidrug-resistant (MDR) microorganisms is a major challenge for global public health in the 21st century. Traditional antimicrobial treatments are losing their effectiveness, making it necessary to look for alternative therapies. Bioactive phytocompounds from medants have shown prosing antimicrobial properties and could serve as valuable resources for developing new antimicrobial agents. This review looks at current knowledge of various phytocompounds, how they work against MDR pathogens, their synergistic effects with standard anttibiot, and thential clinical uses. We discuss major classes of phytocompounds, including alkaloids, flavonoierpenoids, phenolic compouuuunds, annnnnd esseemphasiffectiveness against resistant bacteria, fungi, and parasites. We also address the challenges of standardization, bioavailability, and to with future opportunities for turning these natural compounds into efffective treatments.
Licence: creative commons attribution 4.0
Bioactive comds, multidistance, antimicrobial activity, medicinal plants, alternative therapy
Paper Title: Standardization of A Scientific Knowledge and Aptitude Test
Author Name(s): Dr. Chandra Mukherjee
Published Paper ID: - IJCRT2512227
Register Paper ID - 298420
Publisher Journal Name: IJPUBLICATION, IJCRT
DOI Member ID: 10.6084/m9.doi.one.IJCRT2512227 and DOI : https://doi.org/10.56975/ijcrt.v13i12.298420
Author Country : Indian Author, India, 700078 , Kokata, 700078 , | Research Area: Medical Science All Published Paper URL: http://ijcrt.org/viewfull.php?&p_id=IJCRT2512227 Published Paper PDF: download.php?file=IJCRT2512227 Published Paper PDF: http://www.ijcrt.org/papers/IJCRT2512227.pdf
Title: STANDARDIZATION OF A SCIENTIFIC KNOWLEDGE AND APTITUDE TEST
DOI (Digital Object Identifier) : https://doi.org/10.56975/ijcrt.v13i12.298420
Pubished in Volume: 13 | Issue: 12 | Year: December 2025
Publisher Name : IJCRT | www.ijcrt.org | ISSN : 2320-2882
Subject Area: Medical Science All
Author type: Indian Author
Pubished in Volume: 13
Issue: 12
Pages: b894-b900
Year: December 2025
Downloads: 235
E-ISSN Number: 2320-2882
The main objective of this research is to develop a standardized evaluation for Scientific Knowledge and Aptitude. A total of 100 items were given to 226 students (99 boys and 127 girls, N=226) from classes X, XI, and XII. The study employed Purposive Sampling. To determine reliability, the KR-21 formula was used, resulting in a reliability of .93614 for Life Science, .81553 for Physical Science, .85806 for Mathematics, and .88750 for the overall test. Validity was assessed through inter-item consistency using the inter-correlation method across all subgroups and subtests, with correlations ranging from .488 to .729, and the inter-correlation between subtests and the full test ranged from .773 to .940. For External Validity, the scores from the Madhyamik Examination (class X school leaving certificate examination conducted by the West Bengal Board of Secondary Education) in Life Science, Physical Science, and Mathematics were correlated with the standardized test scores, with correlations ranging from .266 to .663. The study suggests that more randomization is needed in the sampling process.
Licence: creative commons attribution 4.0
Scientific knowledge, Aptitude, Purposive sampling ,Life science ,Physical science, Mathematics, Reliability, validity ,correlation.
Paper Title: Artificial Intelligence and Machine Learning in Personalized Medicine: A Review of Formulation Design Strategies
Author Name(s): Miss. Sugandha Baburao kendre, Mr. Mohammad Zishan Ibrahim
Published Paper ID: - IJCRT2512225
Register Paper ID - 298356
Publisher Journal Name: IJPUBLICATION, IJCRT
DOI Member ID: 10.6084/m9.doi.one.IJCRT2512225 and DOI :
Author Country : Indian Author, India, 431714 , Kandhar , 431714 , | Research Area: Pharmacy All Published Paper URL: http://ijcrt.org/viewfull.php?&p_id=IJCRT2512225 Published Paper PDF: download.php?file=IJCRT2512225 Published Paper PDF: http://www.ijcrt.org/papers/IJCRT2512225.pdf
Title: ARTIFICIAL INTELLIGENCE AND MACHINE LEARNING IN PERSONALIZED MEDICINE: A REVIEW OF FORMULATION DESIGN STRATEGIES
DOI (Digital Object Identifier) :
Pubished in Volume: 13 | Issue: 12 | Year: December 2025
Publisher Name : IJCRT | www.ijcrt.org | ISSN : 2320-2882
Subject Area: Pharmacy All
Author type: Indian Author
Pubished in Volume: 13
Issue: 12
Pages: b873-b886
Year: December 2025
Downloads: 156
E-ISSN Number: 2320-2882
Abstract Artificial Intelligence (AI) and Machine Learning (ML) are increasingly transforming the landscape of personalized medicine by enabling patient-specific therapeutic strategies and optimizing drug formulation design. Personalized medicine aims to tailor treatments based on individual genetic, physiological, and lifestyle factors, improving therapeutic efficacy while minimizing adverse effects. Traditional drug formulation approaches often rely on trial-and-error methods, which are time-consuming and resource-intensive. AI and ML offer powerful tools to overcome these limitations by analyzing complex multidimensional datasets, predicting patient responses, and optimizing formulation parameters such as solubility, stability, and drug release profiles. Recent studies demonstrate that ML algorithms, including supervised, unsupervised, and reinforcement learning, can accurately predict drug behavior and guide the development of novel delivery systems such as 3D-printed tablets, nanoparticles, and controlled-release formulations. Despite their potential, challenges remain, including data quality, regulatory approval, and the interpretability of AI-driven models. Future directions include the integration of multi-omics data, real-world patient information, and explainable AI frameworks to enhance predictive accuracy and clinical applicability. This review summarizes current advancements in AI/ML applications for personalized drug formulation, highlighting trends, key findings, challenges, and prospects for the next generation of patient-tailored therapeutics.
Licence: creative commons attribution 4.0
Keywords: 1. Artificial Intelligence (AI) 2. Machine Learning (ML) 3. Personalized Medicine 4. Drug Formulation Design 5. Predictive Modeling 6. Advanced Drug Delivery Systems 7. 3D Printing in Pharmaceuticals 8. Precision Medicine
Paper Title: THE ROLE OF DIGITAL MEDIA PLATFORMS IN EXERCISING FREEDOM OF EXPRESSION: LEGAL ACCOUNTABILITY AND LIABILITY
Author Name(s): Gourav kumar jain
Published Paper ID: - IJCRT2512224
Register Paper ID - 297580
Publisher Journal Name: IJPUBLICATION, IJCRT
DOI Member ID: 10.6084/m9.doi.one.IJCRT2512224 and DOI :
Author Country : Indian Author, India, 452001 , Indore, 452001 , | Research Area: Commerce All Published Paper URL: http://ijcrt.org/viewfull.php?&p_id=IJCRT2512224 Published Paper PDF: download.php?file=IJCRT2512224 Published Paper PDF: http://www.ijcrt.org/papers/IJCRT2512224.pdf
Title: THE ROLE OF DIGITAL MEDIA PLATFORMS IN EXERCISING FREEDOM OF EXPRESSION: LEGAL ACCOUNTABILITY AND LIABILITY
DOI (Digital Object Identifier) :
Pubished in Volume: 13 | Issue: 12 | Year: December 2025
Publisher Name : IJCRT | www.ijcrt.org | ISSN : 2320-2882
Subject Area: Commerce All
Author type: Indian Author
Pubished in Volume: 13
Issue: 12
Pages: b864-b872
Year: December 2025
Downloads: 191
E-ISSN Number: 2320-2882
The current study examines how online communities are redefining accountability, and create an opportunity for individuals to feel free to exercise their expression. To estimate how social media platforms such as Facebook and Twitter frame international communication, the study relies on secondary data from scholarly research, court cases, and reputable web sources. While all of these digital environments carry the potential for misinformation, hate speech, or the censoring of content, they may also be an opportunity for democratic participation. This study highlights struggle with encouraging free expression confined within democratic values of establishing and regulating protections against harmful expression by codifying human rights protections and balancing regulation with the notion of proportionality. Essentially, it was assessed that the over-regulation of free expression or entirely unregulated free expression was not beneficial for democratic values. The study concludes with recommendations for increasing digital literacy, a more balanced approach to regulating free expression and formalizing accountability mechanisms about expressing one's speech that is open and transparent, in an equitable and safe online space to better encourage free expression
Licence: creative commons attribution 4.0
Freedom of Expression, Digital Media Platforms, Social Media Regulation, Legal Accountability, Platform Liability
Paper Title: The Dynamics of Shared Mobility Adoption: An Extended TAM-TPB Analysis of Two-Wheeler Platforms in Urban India
Author Name(s): Dipesh Lokare, Dr. Hemant Patil, Dr. Archana Patil
Published Paper ID: - IJCRT2512223
Register Paper ID - 298436
Publisher Journal Name: IJPUBLICATION, IJCRT
DOI Member ID: 10.6084/m9.doi.one.IJCRT2512223 and DOI :
Author Country : Indian Author, India, 444001 , Akola, 444001 , | Research Area: Other area not in list Published Paper URL: http://ijcrt.org/viewfull.php?&p_id=IJCRT2512223 Published Paper PDF: download.php?file=IJCRT2512223 Published Paper PDF: http://www.ijcrt.org/papers/IJCRT2512223.pdf
Title: THE DYNAMICS OF SHARED MOBILITY ADOPTION: AN EXTENDED TAM-TPB ANALYSIS OF TWO-WHEELER PLATFORMS IN URBAN INDIA
DOI (Digital Object Identifier) :
Pubished in Volume: 13 | Issue: 12 | Year: December 2025
Publisher Name : IJCRT | www.ijcrt.org | ISSN : 2320-2882
Subject Area: Other area not in list
Author type: Indian Author
Pubished in Volume: 13
Issue: 12
Pages: b858-b863
Year: December 2025
Downloads: 173
E-ISSN Number: 2320-2882
Rapid urbanization, chronic traffic congestion, and the pervasive reliance on private two-wheelers necessitate the scaled adoption of shared, sustainable transport solutions in Indian cities. This empirical investigation addresses the limited academic focus on two-wheeler sharing dynamics by proposing and validating an integrated theoretical framework: the Extended Technology Acceptance Model (TAM) combined with the Theory of Planned Behavior (TPB), augmented by the context-specific variables of Cost-Effectiveness (CE) and Trust and Safety Perception (TS). Primary quantitative data were collected via a structured questionnaire employing a 5-point Likert scale from 120 respondents--predominantly young working professionals and students--across three socio-economically diverse cities (Pune, Vadodara, and Daman). Analysis utilized correlation and multiple regression techniques to test the proposed causal relationships. The empirical findings establish a clear hierarchy of drivers: economic feasibility (CE, Mean=4.32) and functional utility (Perceived Usefulness, Mean=4.21) are the strongest positive predictors of adoption intention. Conversely, Trust and Safety Perception, which registered the lowest mean score (3.78), was identified as the key psychological barrier, directly moderating the conversion of high user intention into consistent, habitual usage. The extended model demonstrated robust explanatory power, collectively accounting for 73% of the variability in user adoption behavior (R^2=0.73). The results confirm the superior utility of incorporating contextual factors in predicting adoption within price-sensitive emerging markets. Managerially, the study underscores the critical need for platforms to invest heavily in operational integrity, visible vehicle quality control, and robust safety protocols to solidify user trust and accelerate the sustainable urban mobility transition.
Licence: creative commons attribution 4.0
Shared Mobility, Two-Wheeler, Technology Acceptance Model, Theory of Planned Behavior, User Adoption, Emerging Market, Cost-Effectiveness, Trust.
Paper Title: Role Of Probiotics And Prebiotics In Gut Health And Immunity
Author Name(s): Aqusa nayyer, Manshi jaiswal, Anchal saroj, Shifa khan, Suraj kannaujiya
Published Paper ID: - IJCRT2512222
Register Paper ID - 298425
Publisher Journal Name: IJPUBLICATION, IJCRT
DOI Member ID: 10.6084/m9.doi.one.IJCRT2512222 and DOI :
Author Country : Indian Author, India, 276305 , azamgarh, 276305 , | Research Area: Health Science All Published Paper URL: http://ijcrt.org/viewfull.php?&p_id=IJCRT2512222 Published Paper PDF: download.php?file=IJCRT2512222 Published Paper PDF: http://www.ijcrt.org/papers/IJCRT2512222.pdf
Title: ROLE OF PROBIOTICS AND PREBIOTICS IN GUT HEALTH AND IMMUNITY
DOI (Digital Object Identifier) :
Pubished in Volume: 13 | Issue: 12 | Year: December 2025
Publisher Name : IJCRT | www.ijcrt.org | ISSN : 2320-2882
Subject Area: Health Science All
Author type: Indian Author
Pubished in Volume: 13
Issue: 12
Pages: b846-b857
Year: December 2025
Downloads: 171
E-ISSN Number: 2320-2882
The human gastestinal microbiome, made up of trillions of microorganisms, acts as a metabolically active organ that plays a crucial role in host physiology, immune development, and susceptibility to disease. Dysbiosis, which refers to an imbalance in microbial community composition and diversity, has been linked to various health issues, including inflammatory bowel diseases, metabolic disorders, neuropsychiatric conditions, and immune dysfunction. Probiotics, defined as live microorganisms that provide health benefits when taken in appropriate amounts, and prebiotics, which are non-digestible food components that stimulate the growth of beneficial microbiota, are effective methods for modifying the microbiome. This review summarizes the mechanisms and clinical evidence supporting the use of probiotics and prebiotics in maintaining gastrointestinal health and regulating the immune system. We explore major probiotic genera like Lactobacillus, Bifidobacterium, and Saccharomyces, their specific effects, categories of prebiotics such as inulin-type fructans and galacto-oligosaccharides, and synbiotic combinations. Strong clinical evidence shows these interventions can prevent antibiotic-associated diarrhea, manage symptoms of irritable bowel syndrome, maintain remission in ulcerative colitis, and shorten the duration of acute infectious diarrhea. Immunological mechanisms include strengthening the epithelial barrier, producing antimicrobial peptides, excluding pathogens, generating short-chain fatty acids, modulating dendritic cell maturation, and inducing regulatory T-cells. While generally considered safe, it's important to pay attention to strain-specific issues, the number of viable organisms, storage conditions, and possible adverse effects in immunocompromised individuals. Global regulations differ, with changing requirements for proving health claims. Future research will focus on next-generation probiotics like Akkermansia muciniphila and Faecalibacterium prausnitzii, postbiotic metabolites, personalized microbiome interventions based on individual profiles, and broader applications in metabolic health, mental wellness, and immune regulation.
Licence: creative commons attribution 4.0
Keywords: Probiotics; Prebiotics; Gut Microbiome; Immunity; Dysbiosis; Short-Chain Fatty Acids; Lactobacillus; Bifidobacterium; Irritable Bowel Syndrome; Intestinal Barrier

