Volume 10 | Issue 2 |

 Abstract

In this study, an in silico molecular docking between the SARS-COV-2 four proteins (a)SARS- COV-2 nucleocapsid protein N-terminal RNA binding domain (6m3m),(b) nsp9 RNA binding protein of SARS COV-2 (6w4b), (c) the crystal structure ofcovid-19 main protease in APO form (6m03), and (d) structure of the 2019-ncov hr2 domain (6lvn)] available in the PDB (protein data bank), and the medicinal plant-based phytochemicals (retrieved from Pub Chem database) as ligand molecules i.e. Piperine (black pepper), eugenol (clove), Alliin (garlic), Gingerol (ginger) and Curcumin (turmeric). All these ligand molecules showed good docking with their respective receptor molecules and their scores range from -8.195 to -5.263. Dockthor with their respective receptor molecules and their scores range from -8.195 to -5.263. Dockthor portal (a receptor ligand- docking server) which was recently developed and published this year was used in the current study. The obtained results might help in the wet lab conditions to develop better antiviral compounds against sars-cov-2.

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Sars-Cov-2, Covid-19, Docking, Phytochemical, Ligand.

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Aim and Objective: Assess the existing knowledge regarding temporary contraceptive methods among primigravida women. Methodology: The study was conducted using Quantitative Research Approach at Krishna Medical Centre. The samples were collected using convenience sampling technique, and Pre experimental research design( one group pre-test post-test design) was used in this study. The conceptual framework utilized in this study was General Systems Theory by Ludwig Von Bertalanffy. A total of 30 samples were selected to be a part of this study. Before conducting the study written consent was obtained from the participants keeping in mind of all the ethics, rules and regulations of the study. The Instrument used had 2 sections in it. The first section consisted of 7 demographic variable questions to obtain a baseline data of every individual participating in the study. And the other half of the section contained 30 structured questions on knowledge regarding temporary contraceptive methods among primigravida women. A pre-test was done to assess their existing knowledge and later an STP was administered to them on temporary contraceptive methods after which a post-test was taken to assess for the effectiveness of my teaching and also to assess their level of knowledge on the same. Result: The result revealed that the Structured teaching programme on temporary contraceptive methods was effective. The researcher observed that initially the primigravida women had inadequate knowledge on the temporary contraceptive methods after which their level of knowledge increased after administration of STP. There was an enhancement of 4 in the mean total. In future, various measures should be taken to improve the knowledge and awareness of temporary contraceptive methods. Discussion: The study concluded that there was a significant enhancement of knowledge among the primigravida women attending antenatal opd after proper administration of STP. Thus the STP was an interactive tool to improve knowledge regarding temporary contraceptive methods.

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Temporary contraceptive methods, Primigravida women, Antenatal OPD, Structured Teaching Programme, Knowledge, Effectiveness.

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As we know that fissure in ano is very pain full anorectal disorders, which is mainly caused by constipation. In today life, constipation is a big problem which is mainly created by faulty diet and life style. If we see in ancient era there was no any disease as like fissure in ano. Although Parikartika is defined in our text which can take same as fissue in ano. Many Ayurvedic Sages defined the Parikartikaas a complication of Panchkarma Therapy (Basti therapy or virechan therapy). But now a days Fissure in ano is described as separate disease. If our younger generation is taking interest as such in flawed Diet (fast food, junk food, spicy food, artificial drinks etc.) and Life style (not performing exercise or Yoga, late night sleep, late morning awake, excess use of smartphone for entertainment, not follow the seasonal regimen, spend more time in toilet and stain during toilet etc.) than there is no such time away when constipation will be count as a separate disease in separate chapter rather than symptoms of anorectal disorders. Constipation is also affected the social and mental status of the person. Ayurveda mainly emphasize on Aahar (Diet) and Vihar (Life style) in each and every disease, which is altered in modern scenario and produces so many anorectal disorders, not only the Anorectal disorders, produces systemic disorders also. So, we can cure the Fissure in Ano (mainly caused by primary cause like constipation) by modification in Diet and life style and also improve the quality of life of patients.

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Keywords: Diet (Aahar), Life style (Vihaar), Constipation, Fissure in ano and quality of life etc.

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These days, the Internet of Things (IoT) network, is progressively turning into an omnipresent availability between various progressed applications, for example, keen urban areas, shrewd homes, savvy frameworks, and numerous others. The arising organization of brilliant gadgets and articles empowers individuals to settle on keen choices through machine to machine (M2M) correspondence. Most true security and IoT-related difficulties are defenseless against different assaults that represent various security and protection challenges. Accordingly, IoT offers productive and successful arrangements. interruption location framework (IDS) is an answer for address security and protection challenges with recognizing diverse IoT assaults. To build up an assault recognition and a steady organization, this present paper's principle objective is to give an exhaustive diagram of existing interruption location framework for IoT climate, network protection dangers challenges, and straightforward issues and concerns are broke down and talked about. In this paper, we propose programming characterized IDS based dispersed cloud design, that gives a protected IoT climate. Experi-mental assessment of proposed engineering shows that it has preferable recognition and exactness over conventional techniques.

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IoT,Security ,IDS

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Background and Objective: A range of research told that there is extensive variations in the sizes and shapes of femur bone across different ethnic groups and geographical locations, thus particular bone-implant fit is challenging to achieve. Prosthesis of mismatched sized can caused serious problems for patients. Thus aim of the study was to design standard hip implant based on anatomical parameter of respective population. Materials and Methods: Eleven osteological parameter of femoral prosthesis of 125 patient (67 male and 59 female) were evaluated, these eleven parameter were grouped to obtain scatter diagram. Then cluster analysis in SPSS software V25 was carried out by using slink clustering method. Results: After studying scatter diagram it was found that 15% population had irregular anatomy then rest of population. So, remaining data put under cluster analysis gives 8 (4 for men and 4 for women) sets of standard anatomical parameter for designing hip implant. Conclusion: These eight standard hip implant satisfy 85% population of Vidarbha region.

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- Hip implant, standard anatomical parameter, femoral prosthesis, mismatched sized, cluster analysis, Slink method, osteological parameter

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 Abstract

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??????????????, ?????????, ???????????, ??????????? ???????? ?

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The Purpose of Quiz Management System is to automate the existing manual system by the help of computerized equipment and full-fledged computer Software, Fulfilling their Requirements, So that their valuable data/information can be stored for a longer period with easy accessing and manipulation of the same. The required software and hardware are easily available and easy to work with. Quiz Management System, as described above, can lead to error free, secure, reliable and fast management system. It can assist the user to concentrate on their other activities rather to concentrate on the record keeping. Basically the project describes how to manage for good performance and better services to the peoples who are taking part in the quiz. The system will show result after the examination is finished. A teacher has control in the question bank and is supposed to make schedule for the quiz. The system carries out the examination and auto-grading for multiple choice questions which is fed into the system. Administrative control of the whole system is provided.

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QUIZ, OFFLINE

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Creative Commons Attribution 4.0 and The Open Definition

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Evolution, Involution, Mind, Matter, Consciousness Force, Delight etc.

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Novel technology had been developed recently for drug delivery systems. Drug delivery is the method of administering the drug or pharmaceutical product, in an effort to acquire favored therapeutic impact. The technique with the aid of using which drug introduced is important, because it has massive impact on its efficacy. Novel drug delivery systems can consist of those based on physical mechanisms and those based on biochemical mechanisms. Physical mechanisms additionally referred as controlled drug delivery systems consist of osmosis, diffusion, erosion, dissolution and electro transport. Novel drug delivery technology have received the significance to acquire modified delivery of drugs there with the aid of using increasing the therapeutic value in addition to decreasing toxicity. In the form of a Novel Drug Delivery System a present drug molecule can get a new life. An accurately designed Novel Drug Delivery System may be a main enhance for fixing the troubles associated toward the release of the drug at particular site with particular rate. But now days with the development with inside the technology, novel drug delivery systems (NDDS) open the door toward the improvement of natural novel drug delivery system. This article covers the basic information regarding Novel Drug Delivery Systems.

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phytosome, liposome, nanoparticles, niosome

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Women are the embodiment of divine virtue and purity, blessed with the sweetness of speech and the beauty of God. The most obvious sign of sexual maturity in girls is menarche. More than a quarter (26%) of the World's Population are women and of reproductive age, and most menstruate monthly. During a woman's life, the lining of the uterus loses and degenerates no less than 400 times. Many girls and women are restricted in their daily life simply because of their menstruation. Impact of menstrual-related myths on women's lives and menstrual taboos in many societies affect the emotional state, mentality and lifestyle of girls and women, and most importantly, their health. But now Menstruation turned out to be a "monthly boon". Researchers have now successfully discovered these stem cells and obtained them from Menstrual Blood via the Menstrual Blood Bank. Menstrual Blood Banks are like a safeguard of your health against future disasters. The Menstrual Blood Banking process is silent, painless, natural and harmless with high patient safety. It is important to note that these blood stem cells can be easily collected, processed and processed during menstruation affordable and inexpensive way collected. painless and non-invasive. As the world is achieving to its greater heights of urbanization and technological advancements, the emerging newer and incurable diseases poses a threat as well as a challenge to medical field. However, recent research has shown that Menstrual Blood is a rich source of stem cells that can multiply and differentiate into any type of cell. These cells have opened up a new field for therapeutic treatment.

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Menarche, Menstruation, Menstrual cycle, Menstrual Blood, Menstrual Blood Banking, Stem cell technology, Menstrual Blood Stem Cells (MenSC).

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