Volume 12 | Issue 3 |

 Abstract

Ocular delivery is one of the most difficult tasks in many existing delivery systems. Liposomes have also been shown to improve drug solubility and distribution control, as well as their ability to modify the surface for targeting, retention, and release. This review is devoted to major and modified liposomal vehicles for ocular drug delivery. There are many methods of ophthalmic drug delivery commonly used in medicine to reach a part of the eye. These drug applications face many challenges to solve issues related to solubility and permeability that depend on the drug application method.

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 Keywords

Keywords: Ocular drug delivery, approaches to enhance ocular drug delivery, Liposomal gel compositions, Method of preparation, Drug loading, Mechanism of drug release through liposome.

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 Abstract

Seven Steps Around the Fire is one of the most famous and renowned drama by Mahesh Dattani. Through his this play Dattani has tried to break all the stereotypes and dogmas which are present in the society regarding the eunuchs. Through the use of refined language and characterization Dattani has tried to subvert all the notions regarding the conventional dramatic structure. Dattani has tried to give voice to the most deprived section of the society by bringing forth the issues related to the life of eunuchs especially of getting married and bearing the progeny. Dattani has tried to streamline them and bring the third gender community on the same page and the work in itself serves as an alarm or reminder to the humanity regarding self introspection.

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stereotypes, dogma, eunuchs, streamline, self introspection

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12 th Century Vachankaartees dedicated their life for social reform. Even their body is sacred as much as mind. Through the body and attitude they attain the position of Sharane and found solvation.

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Vachankaartees, Sharane, Vachana

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The manufacturing industry is facing many challenges today. From higher expectations from customers, to sustainable business practices, the manufacturing industry is dramatically transforming. Now, the adoption of new technologies is imperative for businesses to stay competitive in the age of increased global competition, elevated customer expectations, acute labour shortages, and ever-changing regulations. And, having access to real-time data and the insights it can provide can help avoid risks and prepare businesses for the future. With so much innovation taking place in the manufacturing industry, it is important for businesses to get more insight into what transformative technologies are driving the modern manufacturing movement.

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To study the effectiveness of Digitalization in Manufacturing Industry. To study the organizational opportunities in capturing the market value using Digitalize Technology.

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Introduction The incidence rate of Gridhrasi (sciatica) is quite significant as more than three-quarters of the world's population are affected by the disease. It is characterized by the onset of Ruja (pain), Toda (pricking), and Stambha (stiffness), initially in Sphik (gluteal region) and then radiating distally to Kati-Prishtha (low back), Janu (knee), Jangha (thigh) till Pada (feet). The patients suffering from Gridhrasi have restricted movements due to painful limb, affecting the daily routine activities. Aim To assess the role of Raktamokshana (blood letting) done by cups in the patients suffering from Gridhrasi. Materials and Methods The study was conducted on 15 patients who had reported for the treatment of Gridhrasi at an Ayurvedic hospital Raipur (C.G.). Raktamokshana was done on Sphik, Kati, Jangha, Pada region with the help of 24 no. surgical blade and cups in four settings (0, 7th, 14th and 21st day). The sign and symptoms, namely Ruka, Toda, Stambha, and Spandana (fasiculation) were given scores depending on their severity. The patients were also assessed for straight-leg raise (SLR) test. Follow-up was done at an interval of 15 days for three times and the scores were noted down before and after treatment. Results Marked reduction in severity of mean scores of Ruka, Stambha, Sakthiutkshepa Nigraha and walking time was seen in the patients after the use of Cupping therapy, which was statistically significant. Conclusions Cupping therapy is the simple and effective treatment (in adjunct to other treatment) for reducing Ruka, Toda, Stambha and Spandana in Gridhrasi.

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Cupping therapy, Gridhrasi, sciatica, straight-leg raise (SLR) test.

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An essential component of economic growth is banking. The way that business is performed has changed as information technology (IT) has advanced. Customers can now access cutting-edge technology-based services from banks. The banking industry adopted digital banking in response to technological advancements, enabling their clients to access financial services at any time and from any location. Through the internet, banks are able to communicate with their clients. The banking channel that is expanding the fastest is digital banking. Young people in India are using smartphones at a rapid rate, and mobile banking has developed as a result of these devices' banking apps. The ease of use and convenience of mobile banking has led to a rise in its popularity in recent times. Customers of digital banking can access a wide range of banking goods and services, including the ability to check account balances, transfer funds, pay bills, and access them from any location at any time. Young people are crucial to strengthening our nation. The purpose of this study is to determine and comprehend the main elements impacting the acceptance of digital payments among Indian youth. In this research paper, secondary research is done with the help of questionnaire and quantitative approach was adopted with descriptive statics.

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Youth, Mobile Banking, Digital Payment Platforms, Information Technology (IT).

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 Abstract

halagannada kannada bhodenege upuyuktvada mahitigalu hagu vidhanagalnnu idaralli kanabahudu

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good teaching methed of halagannada kannada bhodenege

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By Utilizing machine learning algorithms, our project presents an innovative approach to predict food choices based on user mood. The system employs the k-means clustering algorithm, an unsupervised learning technique, to create distinct clusters representing moods such as sad, happy, and stressed. Training our system with different data sets, including facial expressions, food reviews, and restaurant information, optimizes the efficiency of mood-based food predictions. The user-friendly interface of our system offers two mood selection options. Users can manually choose their current mood from predefined categories and the other one is by using webcam-based mood detection, where the system captures and analyzes user emotion expressions to predict food choices. The program's front end is designed with Bootstrap, while the back end is implemented using Python and the Flask framework. To enhance the accuracy of food predictions based on user mood, the system integrates facial expression recognition technology. The primary objective of our project is to provide users with user-friendly interaction that makes them helpful while decision-making. Anticipating a 70-plus accuracy rate, this innovation demonstrates the system's commitment to leveraging advanced technologies for mood-based recommendation precision. Our project is of personalized recommendation systems, leveraging advanced technologies to enhance user satisfaction in the realm of food choices based on their current mood. The combination of machine learning algorithms, a user-friendly interface, and innovative features positions your project as a pioneering effort in this domain.

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K-Means Clustering, Sentiment Analysis, Facial Emotion Recognition, Convolution Neural Network (CNN), NLTK.

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Nanorobots, an innovative and developing technology that combines robotics and nanotechnology, has great potential for revolutionising the medical industry. These tiny, self-contained machines, which are generally nanoscale in size, have the potential to precisely move through the human body, carrying out specific functions and dispensing medicines at the cellular and molecular levels. An overview of nanorobot applications in medicine is given in this abstract, with a focus on how they have the potential to revolutionise healthcare. Nanorobots are capable performing a wide range of tasks, including tissue regeneration, medication delivery, diagnosis, and surgery. They can be made to transport therapeutic agents or payloads of medications, enabling targeted, localised illness therapy. Drugs are delivered to the damaged location with the least amount of systemic adverse effects thanks to their capacity to travel through the circulation or enter tissues. Nanorobots with sensors and imaging equipment can diagnose illnesses quickly and with great precision by spotting their early symptoms. Nanorobots can reach difficult anatomical areas and execute minimally invasive treatments, considerably enhancing surgical techniques. They have the capacity to lessen patient suffering, healing time, and complication danger. Nanorobots can also help with tissue healing by moving and assembling biological components at the cellular level, which encourages regeneration processes. Nanorobots provide focused treatments and therapies in personalised medicine, providing promise for the treatment of diseases including cancer, neurological problems, and hereditary abnormalities. They have the potential to improve therapeutic effectiveness and lessen side effects by molecularly customising treatments. The creation and incorporation of nanorobots into clinical practise nevertheless face difficulties, despite these fantastic prospects. These concerns span a variety of areas, including as biocompatibility, power supply, safety, and navigation control. For nanorobots to be used safely and productively in healthcare, it is imperative that these issues be resolved

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Nanorobots, Nanotechnology, Cancer Treatment, Surgery, Medicine,Healthcare, Gene Therapy,Component, Nano-surgery, Disease Management

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Conjunctival melanoma is a rare malignant melanocytic tumor with a bad prognosis due to its recurrence and metastatic potential. Conjunctival melanomas "de novo" or occuring on a nevus have a better prognosis than melanomas associated with primary acquired melanosis, which is a major risk factor for local recurrence and metastatic spread. We report the case of a 51-year-old patient with no particular history who consulted for the first time for a swelling of the inner canthus of the left eye and whose excisional biopsy was in favor of a conjunctival melanoma developed on primary acquired melanosis of the conjunctiva, and who had initially benefited from conservative surgery with external radiotherapy followed by secondary exenteration due to a voluminous endo-ocular recurrence during follow-up.

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Conjunctival melanoma, primary acquired melanosis, recurrence, conservative treatment, exenteration

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