Volume 12 | Issue 3 |

 Abstract

Fast dissolving tablets (FDTs) have revolutionized the pharmaceutical industry as a promising drug delivery system due to their ability to improve patient compliance. FDTs are designed to dissolve rapidly in the oral cavity without the need for water, making them ideal for patients with swallowing difficulties or on-the-go medication administration. They offer a rapid onset of action due to absorption in the pre-gastric area, leading to improved bioavailability. FDTs have advantages such as ease of administration, accurate dosing, improved patient compliance, and rapid onset of action, but also have disadvantages such as taste-masking issues and stability concerns. FDTs are prepared using two technologies: conventional technology and patented technology. Conventional technology includes freeze-drying or lyophilization, sublimation, spray drying, tablet molding, mass extrusion, direct compression, cotton-candy process, nanotization, fast dissolving films, and melt granulation. These techniques can be evaluated using various parameters such as shape, size, thickness, diameter, weight variation, friability, wetting time, hardness of tablet, in vitro/vivo disintegration time, dissolution test, stability study, and drug content.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Novel drug delivery system, Tablet, Fast disolving.

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

The performance of India's equity-based Tier-1 National Pension Schemes (NPS) is assessed in this study for the years 2018 through 2022. It examines the market correlations, risk management, and financial returns of the best-performing pension fund managers using secondary data. The results show that returns have increased significantly for all listed managers, with LIC leading the way and HDFC, Kotak, UTI, and ICICI following. All managers had positive Sharpe ratios, which show returns over the risk-free rate in relation to expected risk, despite their differing levels of success. Based on its highest Treynor ratio, Kotak was the greatest performer in terms of risk-adjusted returns per unit of systematic risk. Nonetheless, weak positive correlations were found with the S&P 500 index, indicating a restricted degree of linkage with market movements. The research highlights the significance of continuous observation and recommends implementing effective tactics, such as risk optimization and diversification, that have been seen in top-performing managers. It also urges more study to overcome shortcomings and improve comprehension of equity-based pension plans in India. The present study provides significant perspectives for investors and policymakers, hence facilitating the progress of retirement planning and financial security in India.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

National Pension Schemes(NPS), Equity-based Tier-1, Scheme E, Pension Fund Managers (PFMs),Performance Evaluation, Risk management.

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

ABSTRACT Background: Kati Graha is a vedanapradhanavyadhi. Patient feels pain and stiffness in the lumbar region, which hampers the normal activities of the person. It is one of the Nanatmajavatavayudhi mentioned by Acharya Sharangadhara. Acharya Shodala and Bhavaprakasha have mentioned Katigraha, as that characterized by Ruja (pain) and Graha (restricted movements) in Kati Pradesh, Hence it is considered as a separate disease in the classical text GadaNigraha. Agnikarma has been given special place in surgery by Sushruta and itis believed that disease treated by agnikarma never reoccurs. Agnikarma is considered as a boon for Sthanikavata and KaphajaVyadhi's and is highly recommended in the management of pain in wide spectrum of disorders. OBJECTIVES OF THE STUDY: To assess the effect of Agnikarma by lohashalaka in katigraha STUDY DESIGN: In present study a median age male patient (32 years) was diagnosed with katigraha and be selected for Agnikurma with Lohashalaka at under points in binduakruti in 4 sitting at interval of seven days with Snehana by Sahacharaditailam for sthanikaabhyanga and Lakshadiguggulu as internal medication. RESULT: Subjective and objective criteria's were statistically analyzed before and after treatment by applying standard statistical method.Agnikarma was found to be highly significant in all Subjective and Objective parameters in the study. CONCLUSION: Agnikarma provided better relief in Katishoola (pain in lower back) Therapeutic Heat of Agnikarma increases the blood circulation locally and flushes away the Pain producing substance. Agnikarma does the action at the level of muscle fibres causing relaxation of muscles thereby improving range of movement. No adverse reaction of therapy was found during and after the treatment. It was concluded that agnikarma therapies with lohashalaka have a definite role in relieving pain and stiffness in katigraha.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Katigraha, Agnikarma, Low back pain, Lohashalaka

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

One of the most popular drug delivery methods is transdermal because it has several benefits, including simplicity of medication application, self-administration, reduced drug metabolism, etc. Despite these benefits, the route still has many drawbacks. The transfer of medications to the systemic circulation through the skin, vagina, ocular, and rectal channels is known as topical drug delivery. Topical formulations are used to treat skin conditions. Although gels have many benefits, hydrophobic medication delivery is one of their main drawbacks. Therefore, an emulsion-based technique is being employed to get around this restriction so that even a hydrophobic medicinal moiety can benefit from gels with special qualities. Emulgel is the name assigned to the dosage form developed by combining gels and emulsions. Emulgel is the promising delivery system for hydrophobic medicines. Emulgel is an emulsion that is gelled in combination with gelling agents. The use of gels is emerging in both cosmetics and pharmaceuticals compared to other semi-solid formulations. Among the many advantages of gels is the major limitation of hydrophobic drug delivery. Therefore, an emulsion-based approach is used to overcome this limitation. Emulgel has several beneficial properties for dermatological use, including Thixotropic, fat-free, easy to apply, easy to remove, flexible, non-staining, long shelf life, transparent and attractive appearance. Therefore, emulgel can be used as a better local drug delivery system than current systems.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Miconazole Nitrate, Emulgel, Gel, Emulsion, Antifungal Activity

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

In recent decades, there has been a significant increase in instances of workplace sexual harassment and gender discrimination within professional environments. Workplace sexual harassment is a term used in legal contexts to refer to repeated and unwelcome sexual conduct that includes verbal, physical, psychological, and visual aspects. It is important to note that workplace sexual harassment often involves actions that can lead to humiliation, insult, and potential harm. The aforementioned conduct encompasses acts of gender harassment, unwelcome sexual attention, and sexual coercion. The spectrum of behaviors encompasses a variety of actions, including but not limited to making sexually suggestive remarks, sharing explicit imagery, and displaying hostility, all with the intention of devaluing the victims involved. The prevalence of harassment exhibits variation in research outcomes as a result of methodological disparities. Workplace sexual harassment is a prevalent issue that is often underreported due to concerns about potential retaliation. The present abstract underscores the significant issue of underreporting. In order to formulate comprehensive prevention and management strategies, it is imperative to have a thorough understanding of underlying factors such as power imbalances, stereotypes, cultural norms, and limited awareness. Proactive measures encompass the implementation of comprehensive anti- harassment policies, educational initiatives, and the cultivation of respectful and inclusive work environments. The practice of effective management encompasses several key elements, including but not limited to transparent reporting, maintaining confidentiality, conducting unbiased investigations, and providing support to victims. The importance of conducting research, promoting awareness, and fostering collaboration cannot be overstated when it comes to establishing secure and inclusive work environments. The occurrence of workplace sexual harassment has significant effects on various aspects of employment, including employee retention, absenteeism, workplace dynamics, and overall well-being. Discussions, which have historically faced societal disapproval, garnered worldwide attention following the emergence of the "MeToo"movement in 2017.The purpose of this research is to evaluate the consequences experienced by victims and the efficacy of current policies and legal provisions in the realm of employment.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Workplace Sexual Harassment, Gender Discrimination, Measurement Tools, Reporting Attitudes, Prevention Strategies, Policies, Legal Regulations.

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Numerous human disorders, such as Alzheimer's, Parkinson's, and type 2 diabetes, are linked to amyloid proteins. Through the regulation of Amyloid protein deposition, some foods and vegetables can assist in the prevention of certain disorders in humans. Onions, kale, tomatoes, cabbage, and romaine lettuce are examples of vegetables. Additional food items such as walnuts, coffee, berries, fatty fish, turmeric, champagne, and cinnamon also assist with the administration of illnesses brought on by the buildup of Amyloids. This experiment uses a dataset that includes the aforementioned dietary items in an attempt to predict amyloid proteins. Neural Net Analysis and Gradient Boosting Classifier are utilized in this data analysis. Under the current system, people with amyloidosis see doctors after developing the illness. Preventing is always better than curing. By forecasting the Amyloids based on dietary habits, the suggested system helps avoid the disease. By enabling people to modify their eating habits, it prevents the occurrence of amyloidosis. The project's goal is to develop a tool for Prediction of Amyloid Proteins using Gradient Boosting Model.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Amyloid Protein, Neural Net Analysis(NNA), Gradient Boosting Classifier(GBC), Prediction of Amyloid Protein, Dietary items.

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

The research examines key financial metrics using a paired samples t-test, focusing on Beta, Sharpe Ratio, Jenson's Alpha, and Treynor Ratio. It finds no significant differences in these metrics, suggesting stability. However, the Sharpe Ratio changes significantly, indicating a shift in risk-adjusted returns. The research also provides insights into Exchange Traded Funds (ETFs) and mutual fund performance, offering practical applications and real-world insights into mutual fund performance. It contributes valuable insights into the performance dynamics of the analysed financial instruments, serving as a valuable resource for researchers, investors, and financial practitioners alike

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

ETFs (Exchange-Traded Funds) Nifty Bees ETF Gold ETFs SEC-registered investment companies Authorized Participants NAV (Net Asset Value) Mutual funds Co-integration Market index returns Securities transaction taxes Pension fund universe

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Abstract: In the present investigation acute toxicity bioassay tests were conducted at various concentrations of Cadmium nitrate ranging from 0.6 to 1.2 mg/l freshwater fish, Channa Puncatatus for 24, 48, 72 and 96 h. The acute toxicity values were determined as 0.90, 0.77, 0.57 and 0.52 ppm respectively under laboratory conditions. These LC50 values showed that the chemical is highly toxic to the fish. Then the fish were exposed to sub lethal concentrations 96 h LC50 0.52 ppm and studied the significant changes histopathoogical changes in stomach and intestine of freshwater fish Channa puntatus. The intestine shows normal structure in control fish but in exposed fish degenerative effect is evident in the mucosal lining and villi of the intestine, rupture of villi at the tip and cracked clay appearance, degeneration of Circular muscle layer swelling in lamina propria were noticed. In the exposed fish stomach shows columnar epithelial cells, degeneration on mucosa, degeneration of villi, Vacuoles in muscular layer, swelling of lamina propria reduction and fusion of stomach microvilli degenerate of the sub mucosal zone. The microvilli lost their normal appearance and become highly folded and vacuole formations, shrinkage of villi were noticed.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Key Word: LC50, Stomach, intestine, Channa punctatus, Cadmium nitrate.

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

??? ?????? ???? ?? ??????? ???? ???? ?? ??? ?????? ?? ???? ?? ?????????? ???? ?? ????? ??????? ?? ????? ?? ???? ???? ???? ?? ???-??? ??? ??????? ?? ??????? ??????? ??????? ??? ???? ?? ?????? ?????? ??????? ?? ?????? ?? ?????? ????? ???? ?? ?????? ???? ???? ??? ?? ??????? ???? ????????? ?????? ????? ?? ??? ??? ??? ?????? ???? ?? ?? ??? ??? ??????? ?? ?????? ?????? ?? ????????? ?? ???? ?? ?????? ???? ?? ?? ??? ?? ?? ?????? ????? ??????? ?? ???? ??? ??? ??? ??? ??? ?? ???? ???????? ?? ???? ???? ??? ????????? ?? ??? ???? ?? ?? ???? ??? ?????? ??????? ?? ???? ???? ?? ???? ?? ??????? ???????? ??? ??????? ?? ?????? ?? ??????? ??? ?? ????? ???? ?? ???? ?? ??? ???????? ??? ?????? ???? ????? ???????? ?? ????? ??? ??????????? ??????? ?? ????? ???? ?? ?? ??? ???????? ?? ?????? ?? ????? ?? ?????? ????? ????????????? ?? ??????????? ?? ??? ???? ??? ?? ??? ?? ??????? ???? ?? ??????? ?? ???? ?? ??????? ??? ????? ??? ?? ??? ????????? ?? ??????? ??????? ?? ?? ??? ?? ????? ??????? ?? ??????? ?? ???? ???? ??????? ?? ??? ?????? ??????? ?? ?? ???? ?? ???

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

??????? ????? ?????? ????

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

The following exploratory article, by a high schooler, seeks to understand shrinkflation, problems created by it and consumer psychology by drawing an analogy between the practice of 'hidden inflation' by companies and a fullback defender in football/soccer (the author plays that position).

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

consumer psychology ,hidden inflation

  License

Creative Commons Attribution 4.0 and The Open Definition