Volume 12 | Issue 5 |

 Abstract

Freedom of the press is not just important to democracy, It is democracy. Media is the medium to convey our thoughts to the world. Media is considered the fourth pillar of democracy. Print media generally refer to newspapers, magazines, and articles. Print media is not just About Facts and information but it Provides us with diverse points of view According to Bill Mayers, 'The quality of democracy and the quality of journalism are deeply entwined' Print media has a great history of boom, Many social reformers began campaigning for radical changes towards the end of the 19th century and all their activity led to a boom in the newspaper industry. At that time print media is the only way to spread their points of view among the folk. Print media not only spread views of a person but sentiments also. We can say democracy needs support of print media and print media needs support of democracy.

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medium, point of view, boom, democracy, media

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Abstract: Prosopis cineraria (fobeaceae) is a small sized tree found in the regions of Arabia and various parts of India such as Rajasthan, Gujarat, Haryana, Uttar Pradesh and Tamil Nadu Prosopis cineraria commonly known as "Khejari" in Rajasthan Dry pods of the plant help in preventing protein calorie malnutrition & iron deficiency in blood, astringent, demulcent and pectoral antimicrobial, free radical scavenging. Leaf extracts shows antidepressant, musclesrelaxtant and antiemetic anti-diarrheal agents Antioxidants, Antibacterial & Antifungal, Leaves are used in eye infections. Barks of the tree used in the treatment of asthma, bronchitis dysentery, Leucoderma and leprosy anticonvulsant Anti-hyperglycemic & Anti-hyperlipidemia prescribed for scorpion sting & snake bite. Procopius Cinararia contain various Alkaloid, Glycoside, and Flavonoids & Phenolic Compounds.

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Key Word: Phytochemical Investigation, different biological activity of Prosopis Cinararia

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Abstract--The report outlines the development of an automated car washing system using Programmable Logic Controllers (PLCs), focusing on efficiency, reliability, and customization. It details the evolution of car washing from manual methods to advanced automated systems, emphasizing the integration of PLC technology for precise control and operation.

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PLC-Controlled Car Wash System

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The investigation of natural compounds derived from medicinal plants for their anti-cancer potential has emerged as a promising strategy in modern drug discovery. Among these natural sources, Asparagus racemosa and Trifolium pratense have garnered attention due to their rich phytochemical composition and traditional medicinal uses. This abstract aims to provide an overview of the in silico studies conducted on the phytochemicals of Asparagus racemosa and Trifolium pratense, specifically focusing on their anti-cancer potential. Asparagus racemosa, commonly known as Shatavari, is a medicinal plant native to India and Sri Lanka. It has been traditionally used in Ayurvedic medicine for various health conditions, including cancer. Phytochemical analysis of Asparagus racemosa has revealed the presence of bioactive compounds such as saponins, flavonoids, and steroidal compounds, which have demonstrated cytotoxic effects against cancer cells in preclinical studies. However, the precise mechanisms underlying the anti-cancer activity of these phytochemicals remain to be fully elucidated. Similarly, Trifolium pratense, or red clover, has been recognized for its medicinal properties and therapeutic potential in various ailments, including cancer. Phytochemicals isolated from Trifolium pratense, including isoflavones, flavonoids, and phenolic compounds, have exhibited anti-cancer effects through multiple mechanisms, such as antioxidant, anti-inflammatory, and anti-proliferative activities. Several in silico studies have been conducted to explore the anti-cancer potential of phytochemicals from Asparagus racemosa and Trifolium pratense. These studies have employed molecular docking to predict the binding affinity of phytochemicals to key proteins involved in cancer pathways, such as kinases, transcription factors, and enzymes. Molecular dynamics simulations have further elucidated the dynamic behavior of protein-ligand complexes, providing insights into the stability and flexibility of binding interactions. Overall, in silico studies of phytochemicals from Asparagus racemosa and Trifolium pratense represent a valuable approach for accelerating the discovery of anti-cancer therapies from natural sources. By combining computational techniques with experimental validation and interdisciplinary collaborations, researchers can unlock the full therapeutic potential of phytochemicals, offering new avenues for cancer treatment and improving patient outcomes. Continued research efforts are warranted to validate the findings of in silico studies and translate them into clinical practice, ultimately benefiting cancer patients worldwide. In the current study, the phytochemicals of Asparagus racemosa and Trifolium pratense with Anti-Cancer potential were studied. Utilizing PubChem and IMPPAT database, the 3D-SDF structures of Asparagus Racemosa and Trifolium Pratense phytochemicals were discovered. The PyMOL software was utilized to convert the ligand file format's 3D structure from SDF to PDB file format. Using SwissADME an excel sheet was created with the physicochemical properties of both Asparagus Racemosa and Trifolium Pratense phytochemicals. The physico-chemical properties considered are molecular weight, H-bond donor, H-bond acceptor, Clog P, Number of rotatable bond, TPSA. (Lipinski's Rule Analysis). Using SwissADME an excel sheet was created with the pharmacokinetics properties of both Asparagus Racemosa and Trifolium Pratense phytochemicals. The GI absorption, BBB permeant, P-gp substrate, CYP1A2 inhibitor, CYP2C19 inhibitor, CYP2C9 inhibitor, CYP2D6 inhibitor, CYP3A4 inhibitor, LOG Kp. The Hypotoxicity, neurotoxicity, nephrotoxicity, respiratory toxicity, cardiotoxicity, carcinogenicity, immunotoxicity, mutagenicity, cytotoxicity, BBB barrier, eco toxicity, clinical toxicity, nutritional toxicity were analysed using ProTox Tool ( ( ProTox-3.0 - Prediction of TOXicity of chemicals (charite.de) ). Molecular docking of phytochemicals of Asparagus Racemosa and Trifolium Pratense was done against 5ILS protein retrieved from RCSB. ( RCSB PDB: Homepage ) . The lowest binding energies were analysed as there is a clear correlation between the proteins low binding energies and their high affinity for their substrates. The protein-ligand interaction was seen through PyMol tool ( PyMOL | pymol.org ) . The phytochemicals with the lowest binding energies can be excellent candidates for Anti-Cancer medicine development.

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Phytochemicals, inhibitor, lowest binding energy, binding affinity

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In contemporary operations, the reliance on signatures for personal identification and transaction authorization introduces a significant fraud vulnerability. Instances of forged signatures have surged, causing substantial financial losses. To address this, we propose a Signature Verification System using Convolutional Neural Network (CNN) technology. Leveraging TensorFlow, Matplotlib, Pandas, and Keras, the system uses geometric measures to analyze signatures and generate a reference for verifications. The goal is to surpass existing methods in reliability, efficiency, and accuracy. Decisions on signature authenticity employ a threshold approach. Parameters in the feature space are meticulously analyzed, and if the absolute difference between the original and verification signature surpasses a predefined threshold, the signature is flagged as potentially forged. This nuanced decision-making process ensures accurate verification outcomes. In conclusion, our Signature Verification System provides a robust, efficient, and accurate solution for detecting forged signatures in various transactions. The incorporation of CNN technology makes it a valuable asset in the ongoing battle against signature-related fraud.

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Signature, CNN, Forgery, Original, Deep Learning

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This study examines how using FinTech (technology in finance) affects how satisfied people are with financial services. We want to know if there's a big connection between these two things. We'll look at different factors like how easy it is to use financial services, how much trust people have in them, and how cost-effective they are. We'll give a survey to people who know about both FinTech and regular finance stuff. Then, we'll use a computer program called SPSS to analyze the answers and see if there's a relationship between using FinTech and being satisfied with financial services. Our results will help banks, government people, and others make smart choices about using FinTech.

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FinTech, financial services, customer satisfaction, technology, accessibility, convenience, trust, security, cost-effectiveness, survey, SPSS, analysis, banks, policymakers, industry professionals.

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 Abstract

Aadhunik awdhi kaviyon ke kavya me samajik awdharna ka bahuvidhi chitran huva hai

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Adarshtmak,kaalpanik, dhirshtpat

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Sustainability, SDGs, digitalisation, and inclusiveness

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The abstract presents a comprehensive study on the design, static structural analysis, and experimental validation of single and double lap joints using ABS material plates bonded with epoxy resin adhesive. The research involves finite element analysis (FEA) to evaluate the structural integrity and load-bearing capacity of the joints under various loading conditions. The ABS material plates, each measuring 160 mm in length, 50 mm in width, and 5 mm in thickness, are bonded together using epoxy resin adhesive with a thickness of 5 mm at the joint interfaces. The study includes the comparison of the adhesive bond strength between epoxy resin and carbon fiber for the double lap joint configuration. Results indicate that the epoxy resin adhesive exhibits higher strength compared to the carbon fiber bond, highlighting its suitability for structural applications. Experimental validation of the double lap joint configuration further confirms the accuracy and reliability of the FEA results. This research contributes valuable insights into the optimization of adhesive bonding techniques for enhancing the mechanical performance of lap joints in composite structures, with implications for aerospace, automotive, and other industries requiring lightweight and durable materials.

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Lap joint, Epoxy resin, carbon fiber, ABS material plate & UTM testing

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The solid dispersion technique has been used as an effective method to improve the dissolution properties and bioavailability of poorly water-soluble drugs. Delafloxacin is an anti-bacterial agent and is used in the treatment of bacterial infections in the body and skin. The present study has demonstrated the possibility of improving the dissolution performance of Delafloxacin, a poorly soluble drug, by using the using the solid dispersion technique using PEG-4000 and HPMC polymers. For the preparation of solid dispersions, various solid dispersion methods (solvent evaporation, fusion method) were used. The effect of several variables on both solid dispersion and preparation ratios was investigated. IR and UV spectral analysis and differential scanning calorimetry were used to characterize solid dispersions. Solid dispersions prepared by various methods were evaluated by methods like saturation solubility, percent drug content, and the in-vitro dissolution method for percent cumulative drug release. Hence, the study strongly recommends that the developed solid dispersion of Delafloxacin can be further utilized for the formulation of suitable dosage forms, such as tablets. Further, the drastic increase in the aqueous solubility of Delafloxacin afforded by the'solid dispersion technique' approach will enable new formulation technologies to be tested in the development of new, more effective anti-bacterial products.

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Solid dispersion, Delafloxacin, Solubility, Dissolutionrate, Anti-Bacterial.

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