Volume 12 | Issue 5 |

 Abstract

Nanotechnology is the science that deals with the process that occurs at molecular level and of nano length scale size. Nano refers to the particle size range of 1-1000 nm. Nanosuspension is an attractive and promising technology to improve poor solubility and bioavailability of the drugs. he following work deals with the special features of nanosuspensions, the preparation methods, advantages of such methods, characterization of nanosuspensions, evaluation parameters and applications of nanosuspension.

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 Keywords

Nanosuspension, particle size, nanotechnology, solubility

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 Abstract

Introduction: Renal artery aneurysm (RAA) is a rare clinical entity that have some predisposing factors, it may cause different complications. Case report: We report the case of a 52-year-old woman, with treatment-resistant arterial hypertension, whose investigations led to the diagnosis of right renal artery stenosis associated with a hilar aneurysm. Endovascular treatment was attempted, but after failure, a right aorto-renal bypass was performed. Conclusion: the aim of surgical treatment of renal artery aneurysm is to eliminate its thromboembolic complications, there is still no consensus on the management of this condition.

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Arterial hypertension revealing renal artery stenosis associated with renal artery aneurysm: about one case with literature review

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This research explores the increasingly significant role of financial marketing through social media platforms in shaping individual investment decisions. In the digital age, social media has become a powerful tool for disseminating financial information, connecting investors, and influencing investment behavior. The research methodology involves a comprehensive literature review, qualitative analysis of social media content, and a quantitative survey of investors across different age groups and income levels. The study aims to uncover the mechanisms through which financial marketing on social media influences investment choices and to identify the key factors that drive investor engagement with financial content on these platforms. Ultimately, this research contributes to a deeper understanding of the evolving landscape of financial marketing in the digital era and its impact on investment decisions. It provides valuable insights for financial institutions, marketers, and policymakers seeking to optimize their engagement strategies on social media platforms to better serve the needs of investors and enhance the overall financial literacy of the population.

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Financial marketing, Investment decision, Investor behavior, Social media platform

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Abstract. CRISPR-Cas9, an acronym for CRISPR-associated protein 9 and Clustered Regularly Interspaced Short Palindromic Repeats, is a revolutionary molecular biology technology that has revolutionized the field of genome editing. Its remarkable accuracy, effectiveness, and adaptability attract interest in many scientific fields. This technique has huge potential for advancing future developments in a variety of industries, including biotechnology, agriculture, and medicine. This review article offers a comprehensive examination of the fundamentals, practical uses, difficulties, and potential future developments of CRISPR-Cas9 technology. The basic mechanisms of CRISPR-Cas9, which emerged from the adaptive immune systems of bacteria, have been explained, insisting on its unique capacity to accurately slice DNA and later rearrange genetic material. CRISPR-Cas9 has been aggressively adopted in a variety of research subject areas, from fundamental genetic study to therapeutic treatments, mainly to its simplicity, efficiency, and adaptability. The capacity of CRISPR-Cas9 to accurately modify disease-causing mutations is one of the technology's most significant uses. This technology has the potential to be used to treat genetic illnesses. The study discusses the progress made in correcting genetic defects in both somatic and germline cells, highlighting the promise of CRISPR-based treatment options for the treatment of inherited disorders. CRISPR-Cas9 has also made it easier to create genetically modified organisms (GMOs) with more desirable characteristics, which has transformed bioengineering and agricultural methods. The significance for responsible governance and public involvement are highlighted as moral and challenges with regulations associated with gene editing technology and genetically modified organisms (GMOs) are reviewed. In alongside genome editing, CRISPR-Cas9 has extended the scope of biological study through the development of revolutionary approaches such as live-cell imaging, epigenome editing, and gene control. The complicated nature of gene expression and cellular functions have been demonstrated by these advancements, providing up the possibilities to new methods of therapy and diagnostic technologies. But there are several obstacles to overcome before CRISPR-Cas9 is widely used. Immune responses, delivery strategies, and off-target effects seem to be major barriers to the practical use of CRISPR-based treatments. To address these issues, ongoing research programs have been highlighted that aim to improve delivery methods, mitigate immunogenicity, and enhance specificity. With plenty of potential for additional research and application, this analysis explores the most recent developments of the technology known as CRISPR, namely base editing, prime editing, and CRISPR-based diagnostics. A new age of precision medicine is also announced by an investigation of the potential of CRISPR-based medicines in the fight against neurological disorders, cancer, and infectious illnesses. At the end, CRISPR-Cas9 is an advanced way that has the potential to have a major impact on genetic research, industry, and medicine. Its accuracy and adaptability provide previously unthinkable opportunities for accurately modifying genomes. CRISPR-Cas9 has a wide range of uses, from looking into complicated genetic features to designing crops, repairing genetic abnormalities, and generating innovative treatments. With its debut, genetic manipulation enters a new age that promises revolutionary breakthroughs that will influence science and technology in the future. Even if there has been a lot of development, more collaboration between disciplines and ethical examination are necessary for optimal use of CRISPR technology while appropriately addressing its limitations.

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Gene editing, Genetic Engineering, Molecular biology, Biotechnology

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: In order to protect public health and safety, particulate matter (PM) monitoring in residential construction sites is crucial. Traditional monitoring methods often involve expensive equipment and complex procedures, limiting their accessibility and scalability, particularly in resource-constrained settings. This study explores the feasibility of utilizing cost-effective dust sensors for real-time PM monitoring in construction residential environments, with a focus on sites in Pune. A comprehensive assessment of the performance of these sensors was conducted through deployment in various construction sites across Pune, measuring PM concentrations over extended periods. The results demonstrate the efficacy of the cost-effective dust sensors in providing timely and accurate PM data, enabling proactive management of air quality in construction areas. The findings highlight the potential of these sensors to enhance environmental monitoring practices and support sustainable development initiatives in urban construction projects. This research contributes to advancing the adoption of affordable technologies for effective PM surveillance, thereby promoting healthier and more liveable communities amidst construction activities in Pune and similar urban settings.

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Particulate matter, Air Quality Impact, Low-cost dust sensor, Construction site, Real time monitoring

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Ground Granulated Blast Furnace Rag (GGBS) has emerge as a prominent cement replacement material in the construction industry 'cause of its numerous advantageous properties. This study investigate the feasibility and effectiveness of utilizing GGBS as a partial replacement for cement in concrete production, you know. Through a comprehensive literature review and experimental analysis, the study explore the impact of GGBS substitution on various properties of concrete, including strength, durability, workability, and sustainability aspects, you know. Different concrete mixtures with varying percentages of GGBS replacement are evaluate to determine the optimal dosage for achieving desired performance characteristics.

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paper publication

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Herbal medicine sometimes referred to as botanical medicine or herbalism it involves the use of plants or parts of plants to treat injuries or illness. Seeds, leaves, stems, bark, roots, flowers, and extracts of all of these have been used in herbal medicine over the millennia of their use. Some of the pharmaceutical medications on the market are extracts of some of these traditional herbs. The lower cost, and often safer use, has attracted many medical professionals. Plants had been used for medicinal purposes long before recorded history. Ancient Chinese and Egyptian papyrus writings describe medicinal uses for plants. Indigenous cultures (such as African and Native American) used herbs in their healing rituals, while others developed traditional medical systems (such as Ayurveda and traditional Chinese medicine) in which herbal therapies were used.

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Analgesic, Aloe vera, Polyherbal, Extraction, Formulation, Evaluation.

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Global biodiversity is progressively declining. The current rate of extinction is greatly influenced by both direct and indirect human action. Future biodiversity protection depends on our ability to identify plants accurately and comprehend their spatial distribution. Therefore, the management and study of biodiversity depend heavily on the prompt and accurate identification of plants. Various plant features are used as identification keys by botanists throughout the manual identification procedure. Then, in order to identify different plant species, these keys are gradually and adaptively analysed. By answering a series of questions about one or more characteristics of an unknown plant (such as shape, colour, number of petals, presence of thorns or hairs), an identification key user is essentially focusing on the most distinctive aspects and decreasing the number of features that the plant has in common.

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Identification, analysis, species, origins, leaves, classification, recognition

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Q fever is a zoonotic disease considered as emerging or re-emerging in many countries.It is caused by Coxiellaburnetii, a bacterium developing spore-like forms that are highly resistantto the environment.Coxiellaburnetiiis most commonly transmitted tohumans by direct contact with the reproductive tissuesof cattle, sheep, and goats in which the causativeorganism reaches exceptionally high titers. Q fever has been reportedworldwide with the exception of Newl. Zealand. The overall mortality rate for Q fever is 1-2% in untreated cases, and lower in those who are treated. Humans infected with C. burnetiioften seroconvert without clinical signs or develop a mild, self-limited, flu-like illness.Animals are thought to become infected during direct contact, via routes such as inhalation and ingestion, or by aerosols. Infectious airborne particles have been reported to travel up to 11 miles.

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Introduction, history, pathophysiology, diagnosis, treatment,Doxycycline

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One of the applications for optical immunosensors is in optical-based detection systems that act on luminescence, fluorescence, reflectance, absorbance, and so forth.Immunological tactics rely on an antibody's (monoclonal, polyclonal, or engineered) clear restriction to an antigen.Immobilizing explicit antibodies onto a transducer that is guaranteed to provide an unending supply of common micro-organisms and microbial poisons is necessary for the identification of explicit micro-organisms and microbial poisons. Immunosensors inherent advantages, such as their explicitness, responsiveness, speed, ease of use, and on-site evaluation is a tool that has several applications. strength for the swift and delicate detection of diverse food and beverage kinds, along with food- and water-borne micro-organisms, toxins, and pesticide buildups with great particularity. Biosensors provide appealing, practical options by offering dependable and speedy demonstrations.There is a lot of promise in using biosensors in Indian food and bioprocessing companies to assess the safety and quality of food. The food industries require quick and inexpensive technologies to guarantee product quality and process control. Due to their inherent specificity, selectivity, and simplicity of biosensors, which combine a sensitive transducer with a biological recognition element, are adaptable analytical instruments with benefits over conventional analytical techniques.

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Biosensors, Nourishment handling, CFTRI, Nano -sensor,Aptameter,Immunosensor,Chemical Electrode,Amprometric Biosensor.

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