Volume 9 | Issue 8 |

 Abstract

Introduction. Breast cancer is a problem that is still faced throughout the world. The incidence of cancer in Indonesia is at number 8 in Southeast Asia. The incidence of breast cancer in women is 42.1 per 100,000 population. Aromatase inhibitors are hormonal therapy used in postmenopausal breast cancer with positive ER and/or positive PR. The third generation aromatase inhibitors are divided into 2 categories, namely non-steroidal agents that are reversible and steroid agents that are irreversible. Based on existing studies, there are no consistent research results regarding the incidence of recurrence after aromatase inhibitor therapy, both steroids and non-steroidal. Methods. This study is an analytical observational study with a retrospective cross- sectional design using secondary data from medical records. The research was carried out at the Surgical Clinic of RSUD dr. Soetomo Surabaya on October 1, 2020 until the end with the subject of LABC patients at POSA Surgery RSUD Dr. Soetomo who has undergone mastectomy and radiotherapy and has received adjuvant hormonal aromatase inhibitor therapy for 2 years from January 2018 to January 2020. Results. In the nonsteroidal aromatase inhibitor group, 18 subjects (60%) experienced recurrence and 16 subjects in the steroid aromatase inhibitor group (32%) with an OR of 0.314 (0.12-0.81; p=0.014. Based on the results of multivariate analysis, it was found that the increased risk of recurrence was significantly affected only by the administration of aromatase inhibitor p= 0.052 Conclusion. Women with locally advanced breast cancer after mastectomy who received aromatase inhibitor steroid therapy had a 0.314 times lower risk of recurrence than those who received non-steroidal aromatase inhibitor therapy.

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Breast cancer, aromatase inhibitor steroid, recurrence

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This new species has been found in the Intestine of fish Barilius Barana (Ham.) collected from River Ganga in district Kanpur. Out of these only two specimens were found infected with six trematode worms. The experiment was carried out from the laboratory from August to October.

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Barilius Barana (Ham.), Intestine, Allocreadiun Kanpurensis.

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The Sieved biomass of Ailanthus excelsa was chemically treated with Sulfuric acid (H2SO4) to produce acid- factionalized biosorbent used for O-Nitro Phenol removal from aqueous environment. Various analytical techniques were utilized to investigate the surface area, surface morphology, crystallinity, elemental composition of the sulfuric acid-treated biomass for removal of O-Nitro Phenol. Batch experiments were carried out as functions of different process parameters such as pH, initial dye concentration, biosorbent dose and temperature. The optimum conditions for removal of ONP were found to be pH (2.0), biosorbent dose (50 mg), and initial dye concentration (100 mg L-1).The temperature (288K) had a strong influence on the biosorption process. The Langmuir, Freundlich and Temkin isotherms model, sorption of ONP onto SBAE were studied. The rate of sorption was found to obey pseudo-second order kinetics and intraparticle diffusion model with correlation coefficient value R2 is 0.9981. Thermodynamic studies showed that the biosorption process was spontaneous and exothermic. The sieved SBAE is a promising biosorbent for ONP removal from aqueous solutions.

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Sulphonated Biomass of Ailanthus excelsa (SBAE), O-Nitro Phenol (ONP), Isotherm study

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Abstract: Background: India has successfully brought down maternal mortality ratio (MMR) by 9 points in one year, as per data released by the Registrar General of India. Rajasthan and Uttar Pradesh are among the states that have shown most decline. Labour and birth are an amazing integration of powerful physiological and psychological forces that bring a new human life into the world. The woman may be apprehensive about entering an unknown, and perhaps threatening, hospital environment and concerned about relinquishing her personal autonomy and identity. Especially the first stage of labour is the longest in duration as compare to the other two stages. Early identification of complications and prevention helps a long way in reducing maternal fetal morbidity and mortality since the labouring and birthing process is a life-changing event for many women. Nurses need to be respectful, available, encouraging, supportive, and professional in dealing with all women. The nursing management for labor and birth should include comfort measures, emotional support, information and instruction, advocacy, and support for the partner. Objectives: To assess the knowledge of final year GNM students regarding nursing management of first stage of labour by using structured knowledge questionnaire, to find the association between knowledge score and selected demographic variables. Material and methods: Data were collected from 50 samples from selected school of nursing Data were collected by using structured knowledge questionnaire. The demographic variables analyzed in the study were age, sex, religion and source of information. The study sample was selected by a non- probability convenience sampling technique. Data obtained were tabulated and analyzed in terms of objectives of the study using descriptive and inferential statistics. Results: The study revealed that 50 % had adequate knowledge, 18 % had inadequate knowledge and 32 % had moderate knowledge. There was significant association between age and source of information. There was no association between the sex and religion of the Final year GNM students. Conclusion: The findings of the study revealed that educating the students would be effective in updating the knowledge and skills regarding management of first stage of labour.

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Keywords: Knowledge, Selected demographic variables, First stage of labour.

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Mixed solvency, Poorly water soluble drugs, Titrimetry, UV Spectrophotometry, TLC, harmful organic solvents, green chemistry

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: Generating a fraudulent communication that appears to come from a reputable source is known as phishing. The most widely used mode of communication is e-mail. The purpose is to steal personal information like credit card numbers and login credentials, or to infect the victim's machine with malicious software. Phishing is a common type of cyberattack that everyone should be aware of. Phishing starts with a phone call, e-mail, or other form of communication designed to entice a victim. The communication looks to come from a reliable source in this form of attack. If the attacker is deceiving the victim, it is usually advised to give crucial information to a fraudulent website. Malware can be downloaded on occasion downloaded to the machine that could be used as a target Attackers profit financially by collecting their victims' credit card information or other personal information. Phishing e-mails are occasionally sent to employees in order to get login information or other personal information in order to conduct a complex attack on a company. Phishing is a popular entry vector for cyber-attacks like Advanced Permanent Threats (APT) and ransomware. During a phishing assault, attackers can collect background information about the victim's personal and professional history, hobbies, and activities by using social engineering and other public information resources, such as social networks like LinkedIn, Facebook, and Twitter.

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Phishing, Forensic analysis, NLP Algorithm, Random Forest, Cybersecurity.

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Multilevel inverters have been widely accepted for high-power high-voltage applications though the multilevel inverters hold attractive features, usage of more switches in the conventional configuration poses a limitation to its wide range application. Therefore, 7-level inverter topology is introduced using less number of switches and gate trigger circuitry, thereby ensuring the minimum switching losses, reducing size and installation cost. Multilevel inverter (MLI) plays a vital role in the field of power electronics and being widely used in many industrial and commercial applications. The multilevel inverter topology is the proper option from the point of view of modularity and simplicity of control.

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Multilevel DC to AC inverter, PIC Microcontroller, SPWM.

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pulsating, culminating, pertinent, bhagavatism, emergence, genesis

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Population, Health, Development, Coronavirus, Economy

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Background: One of the most aeroallergen causing allergy disease is house dust mite (HDM). Skin prick test (SPT) has high specificity and sensitivity for diagnosing allergy due to inhaled substances. Immunotherapy should be initiated whenever there is positivity of house dust mite skin prick test result. Objective: This study aimed to investigate the efficacy of immunotherapy based on induration diameter of skin prick test result to house dust mite allergen. Methods: This retrospective study was conducted in Pediatric allergy and immunology outpatient clinic of Dr. Soetomo General Hospital Surabaya. Medical record was taken from January 1st until December 31st 2020 period. House dust mite allergy was diagnosed based on positivity of skin prick test to HDM. Immunotherapy efficacy was evaluated with daily symptom score (dSS), daily medication score (dMS), and Combined Symptom and Medication Score (CSMS) at least 3 months after immunotherapy. Age, gender, duration of illness, nutritional status, family history of atopic allergic disease, and other allergic comorbidities were stipulated as confounding variable. Statistical analysis were normality distribution test, wilcoxon rank test, spearman test, and regression analysis. Results: Sixty patient of HDM allergy (33 boys and 27 girls), were included in this study. Significant alteration of dSS, dMS, and CSMS before and after immunotherapy evaluated with wilcoxon rank test result (p=0.000 respectively). There was no correlation of each confounding variables to induration diameter of SPT. Positive correlation between induration diameter and CSMS score was tested with Spearman test (p=0.003, r= 0.373). Conclusions: Smaller induration diameter of HDM SPT result could be predictive for immunotherapy efficacy.

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 Keywords

House dust mite; skin prick test; induration diameter; immunotherapy; symptom score; medication score

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