Volume 9 | Issue 8 |

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carbon nanotubes, cancer, therapy, carrier, mediators

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Creative Commons Attribution 4.0 and The Open Definition

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The COVID-19 pandemic will undeniably transform the way we live and work for the predictable future, and new trends will emerge that will become part of our new normal. In the Indian circumstance, the impact of COVID-19 outburst appears devastating. With the national GDP falling into negative numbers, the country seems like facing one of its horrible economic recessions. The real estate sector touched the lowest of lows during the nearly three-month-long national lockdown. The real estate industry in India has experienced a slowdown in the advancement of projects under construction and delayed consumer decisions to purchase the properties. Some of the challenges faced by the industry are the liquidity crisis, migration of workers and interruptions in the supply chain for building materials. Furthermore, the sentiment in the market has become worse in recent times. This paper outlines the major real impact of Covid-19 on Indian real estate industry. And also present some Indian government initiatives which would benefit the sector and take it to its glorious past.

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Key words: Real Estate, Covid 19, liquidity crisis, Government initiatives

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With the progression in the field of Chronobiology, modern drug delivery approaches have been raised to another idea of chronopharmacology. however, the major limited access in the improvement of drug delivery system that coordinate the circadian rhythm chronopharmaceutical drug delivery system (ChrDDS) might be the accessibility of proper innovation. The most recent decade has seen the rise of ChrDDS against a few illnesses. This review presents the idea of chronopharmaceutics, addresses hypothetical/formal ways to deal with this sub-discipline, underscores potential disease targets, returns to existing advances and instances of ChrDDS. Future improvement in chronopharmaceutics might be made at the interface of other developing techniques, for example, system biology and nanomedicine. The expanding research in ChrDDS may lead to the formation of another sub-discipline in pharmaceutics known as chronopharmaceutics.

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Chronopharmaceutics, Chronotherapeutics, Circadian rhythm, Chronopharmaceutical technology, Chronopharmacology.

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Background and purpose: Adhesive capsulitis is a syndrome defined in its purest sense as idiopathic painful restriction of shoulder movement that results in global restriction of the glenohumeral joint.Loss of ROM, especially that of external rotation and pain in subjects with adhesive capsulitis results in severe functional impairments, especially overhead activities. Mobilizations are means of increasing joint mobility and decreasing pain by passively gliding the joint surfaces to stretch the capsule that has been shown to be effective by various researches throughout the globe. Muscle energy techniques are a newer technique that focuses on contractile elements to reduce pain, increase ROM and improve function. Methodology: 32 samples of adhesive capsulitis were selected by convenient sampling technique. Total study duration was of 2 months. Samples were randomly divided in to 2 groups. Conventional exercises were given in both the groups. In 1st group MET was given in addition to conventional exercise and in 2nd group Maitland mobilization was given. Total protocol was of 1 month,5 days a week ,twice a day. Two outcome measures were used.NPRS for Pain and Active External Rotation and abduction ROM (Using Universal Goniometer). Data analysis and Result: The data has been analysed using SPSS version 16. The significance level had been kept at 95%. The data has been screened for normality before applying any statistical tests. Changes in the outcome measures have been analysed within groups as well as between groups. NPRS in both the groups ROM in both the groups Conclusion: The present study found significant improvements in pain and ROM in both groups. Yet, greater improvement is found in MET group for pain and ROM as compared to Maitland group.

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Key-words: Adhesive capsulitis, MET, Maitland

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Targeting tumor-driven angiogenesis is a successful method for treating metastatic colorectal cancer (mCRC); however, the availability of multiple medicines, the incidence of resistance, and the paucity of data make selecting a second-line therapy difficult. Numerous prognostic and predictive biomarkers that have been verified The use of in this review is looked at. Second-line management with angiogenesis-targeted medicines Angiogenesis, or the formation of new blood vessels, has been targeted for the treatment of colorectal and other cancers through a variety of pathways and molecules. Angiogenesis is thought to be mediated by the binding of vascular endothelial growth fact Therapy for metastatic colorectal cancer (m CRC) has evolved significantly since the late 1990s, and now includes a combination of doublet or triplet chemotherapy and a targeted agent. Angiogenesis, or the formation of new blood vessels, can be targeted a crucial component of the overall treatment plan Since the first anti-angiogenesis drug was approved in 2004,multiple drugs or (VEGF)-A to VEGF receptor (VEGFR)-2. VEGF pathways in other animals VEGF-A, VEGF-B, and placental GR all play a role in angiogenesis.

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Angiogenesis, Vascular endothelial growth factor, Colorectal cancer

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When cancer starts in a woman's reproductive organs, it is called gynecologic cancer. The five main types of gynecologic cancer are cervical, ovarian, uterine, vaginal, and vulvar. (A sixth type of gynecologic cancer is the very rare fallopian tube cancer.) ?-Peltatin (Apoptosis inhibitor 5) is an anti-apoptotic factor that confers resistance to genotoxic stress in human cancer. ?-Peltatin is also expressed in endothelial cells and participates in the Estrogen Receptor ? (ER?) signaling to promote cell migration. In this study, we found overexpression of ?-Peltatin in human ovarian cancer. Given that we show that high expression of ?-Peltatin in ovarian cancer patients is associated with shorter recurrence- free survival, we investigated the relationship between ER? and ?-Peltatin at the molecular level. We found that the ?-Peltatin Nuclear Receptor box (NR box) drives a direct interaction with the C domain of ER?. Furthermore, ?-Peltatin participates in gene transcription activation of ER? target genes upon estrogen treatment. Besides, ?-Peltatin expression favors tumorigenicity (is the tendency for cultured cells to give rise to either benign or malignant growing tumors when infected to immunologically nonresponsive animals) and migration and is necessary for tumor growth in vivo in hen xenografted model of an ovarian cancer cell line. These findings suggest that ?-Peltatin is a new cofactor of ER? that functionally participates in the tumorigenic phenotype of ovarian cancer cells. In ER? ovarian cancer patients, ?-Peltatin overexpression is associated with poor survival and may be used as a predictive marker of ovarian cancer recurrence-free survival.

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?-Peltatin, Estrogen-receptor (ER), Ovarian cancer, In vitro, In vivo, Apoptosis, Genotoxic, Tumorigenicity, DNA, Cell Signaling.

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DETECTION OF TEMPERATURE AND CO CONTENT IN SERVER ROOM

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WSN TEMPERATURE DETECTION SENSORS

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E-learning Readiness, Item analysis, Reliability, Validity, Norms

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-life balance, job satisfaction, paramedical professionals, work load, performance

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A majority of youth in developing countries are in the low- income families where development constraints pose additional challenges to youth due to their limited access to resources, education and training, health care, employment and broader socio-economic development opportunities. The parents have few resources to invest in them and, as a consequence, their homes have the fewest cognitively stimulating materials, and their parents invest less in their education. The stress of living in poverty and struggling to meet daily needs can also impair parenting. The present study explores the elements of the intergenerational mobility among the lower-income families of scheduled caste communities predominant in Puducherry. A quantitative and qualitative approach is used to analyse the intergenerational mobility process. The educational status, occupational experience, family background, socioeconomic status, income variation, school, and college experience, and impact on caste and the government policy, political activities and geographical locations related to research are critically examined and consolidated in the study. They are still performing the traditional occupation and the occupation has even transformed to the next generation too. The government took many initiatives to uplift the socially disadvantaged people through implementing various schemes free educations, scholarships, free hostel, reservation policies to provide for the Dalit youth. Through these schemes, many youths have benefited from this category.

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Social Mobility, Intergenerational Mobility, Education, Occupation, Dalit and Youth.

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Creative Commons Attribution 4.0 and The Open Definition