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MECHANISMS AND EFFECTS OF CHRONIC TOXICITY IN HUMANS WITH SPECIAL REFERENCE TO DUSHIVISHA: A COMPREHENSIVE REVIEW
Authors
Dr. Mithilesh Shakywal,Dr. Manpreet Kaur,Dr. Nitika Kunwar Shaktawat
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Keywords
Keywords: Chronic toxicity, Dushivisha, Bioaccumulation, Oxidative stress, Heavy metals, Ayurveda, Detoxification, Chronic disease, Environmental toxins, Systems-based toxicology
Abstract
Background: Chronic toxicity is an emerging public health concern marked by the gradual accumulation of low-level toxic substances within human tissues leading to progressive multisystem dysfunction. While modern toxicology effectively identifies individual toxins and acute mechanisms, it often struggles to address the cumulative and synergistic effects of long-term, low-dose exposure. The Ayurvedic concept of Dushivisha which is defined as a partially neutralized toxin that persists in the body, offers a complementary, systems-based framework for understanding chronic toxicity.
Objective: To explore and analyze the concept of Dushivisha from Ayurveda in the context of chronic toxicity and to correlate its classical descriptions with contemporary toxicological mechanisms such as oxidative stress, bioaccumulation, enzyme inhibition and mitochondrial dysfunction. The study further aims to evaluate the relevance of an integrative approach combining Ayurvedic detoxification principles with modern medical perspectives for a more comprehensive understanding and management of chronic low-dose toxic exposure.
Methods: A systematic literature review has been undertaken utilizing multiple academic databases including PubMed, Google Scholar, Science direct , classical ayurvedic texts (eg.Charak Samhita, Sushrut Samhita) and Ayurveda focused repositories such as Ayush Research Portal.
Result: Dushivisha represents a chronic, low-grade toxic state distinct from acute poisoning, where accumulated toxins weaken digestion (Agni) and generate Ama, promoting inflammation. Long-term exposure to toxins causes oxidative stress and multi-organ damage. It leads to tissue dysfunction, channel blockage and chronic conditions, paralleling modern toxins like pollutants, chemicals and heavy metals.
Discussion: The Ayurvedic concept of Dushivisha explains chronic toxicity by addressing cumulative, low-dose exposures often overlooked in modern toxicology. It correlates with bioaccumulation and systemic dysfunction seen in chronic diseases. Ayurvedic therapies, including detoxification and rejuvenation, along with formulations like Dushivishari Agada, offer a holistic approach for managing long-term toxic effects.
Conclusion: The concept of Dushivisha remains highly relevant today in explaining chronic toxicity and lifestyle diseases. Gradual toxin accumulation can disrupt multiple body systems over time. Combining Ayurvedic insights with modern science supports better understanding and management. Preventive care, detoxification and rejuvenation therapies offer practical strategies while further research can strengthen integrative public health approaches.
IJCRT's Publication Details
Unique Identification Number - IJCRT2606550
Paper ID - 310625
Author type - Indian Author
Page Number(s) - f109-f118
Pubished in - Volume 14 | Issue 6 | June 2026
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No Of Downloads - 80
Author Country - India, 313001, Udaipur, Udaipur, 313001, Humanities All
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Dr. Mithilesh Shakywal,Dr. Manpreet Kaur,Dr. Nitika Kunwar Shaktawat, "MECHANISMS AND EFFECTS OF CHRONIC TOXICITY IN HUMANS WITH SPECIAL REFERENCE TO DUSHIVISHA: A COMPREHENSIVE REVIEW", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.14, Issue 6, pp.f109-f118, June 2026, Available at :http://www.ijcrt.org/papers/IJCRT2606550.pdf
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